Bioactive compounds and probiotics-a ray of hope in COVID-19 management

doi:10.1016/j.fshw.2021.02.001

Review

. 2021 Mar;10(2):131-140.

doi: 10.1016/j.fshw.2021.02.001. Epub 2021 Mar 22.

Bioactive compounds and probiotics-a ray of hope in COVID-19 management

Indu Bhushan¹, Mahima Sharma¹, Malvika Mehta¹, Shivi Badyal¹, Varun Sharma², Indu Sharma², Hemender Singh¹, Srinivas Sistla³

Affiliations

¹ School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India.
² Birbal Sahni Institute of Palaeosciences, Lucknow, UP, India.
³ Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, USA.

PMID: 38620836
PMCID: PMC7982983
DOI: 10.1016/j.fshw.2021.02.001

Review

Bioactive compounds and probiotics-a ray of hope in COVID-19 management

Indu Bhushan et al. Food Sci Hum Wellness. 2021 Mar.

. 2021 Mar;10(2):131-140.

doi: 10.1016/j.fshw.2021.02.001. Epub 2021 Mar 22.

Authors

Indu Bhushan¹, Mahima Sharma¹, Malvika Mehta¹, Shivi Badyal¹, Varun Sharma², Indu Sharma², Hemender Singh¹, Srinivas Sistla³

Affiliations

¹ School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India.
² Birbal Sahni Institute of Palaeosciences, Lucknow, UP, India.
³ Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, USA.

PMID: 38620836
PMCID: PMC7982983
DOI: 10.1016/j.fshw.2021.02.001

Abstract

The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time. Anti-viral, anti-inflammatory and anti-allergic properties of bioactive compounds and bacteria with probiotic properties in respiratory viral diseases may have significance to enhance immunity. This review highlights some of the important bioactive compounds and probiotic bacteria, suggesting them as a ray of hope in the milieu of the COVID-19 management.

Keywords: Bioactive compounds; COVID; Food; Metabolites; Probiotics.

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Figures

**Fig. 1**
Two-way strategy showing the use of food bioactives as inhibitors of viral S protein and host ACE2 receptor.

**Fig. 2**
Network analysis of the genes involved in the lactose metabolism and SARS-CoV-2 infection.

See this image and copyright information in PMC

References

1. Kris-Etherton P.M., Hecker K.D., Bonanome A., et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002;113(Suppl 9B):71S–88S. doi: 10.1016/S0002-9343(01)00995-0. - DOI - PubMed
1. Siriwardhana N., Kalupahana N.S., Cekanova M., et al. Modulation of adipose tissue inflammation by bioactive food compounds. J. Nutr. Biochem. 2013;24(4):613–623. doi: 10.1016/j.jnutbio.2012.12.013. - DOI - PubMed
1. Carbonell-Capella J.M., Buniowska M., Esteve M.J., et al. Effect of Stevia rebaudiana addition on bioaccessibility of bioactive compounds and antioxidant activity of beverages based on exotic fruits mixed with oat following simulated human digestion. Food Chem. 2015;184:122–130. doi: 10.1016/j.foodchem.2015.03.095. - DOI - PubMed
1. Hassimotto N.M., Genovese M.I., Lajolo F.M. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. J. Agric. Food Chem. 2005;53(8):2928–2935. doi: 10.1021/jf047894h. - DOI - PubMed
1. Yan F., Polk D.B. Probiotics and immune health. Curr. Opin. Gastroenterol. 2011;27(6):496–501. doi: 10.1097/MOG.0b013e32834baa4d. - DOI - PMC - PubMed

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[1] Kris-Etherton P.M., Hecker K.D., Bonanome A., et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002;113(Suppl 9B):71S–88S. doi: 10.1016/S0002-9343(01)00995-0. - DOI - PubMed

[2] Kris-Etherton P.M., Hecker K.D., Bonanome A., et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002;113(Suppl 9B):71S–88S. doi: 10.1016/S0002-9343(01)00995-0. - DOI - PubMed

[3] Siriwardhana N., Kalupahana N.S., Cekanova M., et al. Modulation of adipose tissue inflammation by bioactive food compounds. J. Nutr. Biochem. 2013;24(4):613–623. doi: 10.1016/j.jnutbio.2012.12.013. - DOI - PubMed

[4] Siriwardhana N., Kalupahana N.S., Cekanova M., et al. Modulation of adipose tissue inflammation by bioactive food compounds. J. Nutr. Biochem. 2013;24(4):613–623. doi: 10.1016/j.jnutbio.2012.12.013. - DOI - PubMed

[5] Carbonell-Capella J.M., Buniowska M., Esteve M.J., et al. Effect of Stevia rebaudiana addition on bioaccessibility of bioactive compounds and antioxidant activity of beverages based on exotic fruits mixed with oat following simulated human digestion. Food Chem. 2015;184:122–130. doi: 10.1016/j.foodchem.2015.03.095. - DOI - PubMed

[6] Carbonell-Capella J.M., Buniowska M., Esteve M.J., et al. Effect of Stevia rebaudiana addition on bioaccessibility of bioactive compounds and antioxidant activity of beverages based on exotic fruits mixed with oat following simulated human digestion. Food Chem. 2015;184:122–130. doi: 10.1016/j.foodchem.2015.03.095. - DOI - PubMed

[7] Hassimotto N.M., Genovese M.I., Lajolo F.M. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. J. Agric. Food Chem. 2005;53(8):2928–2935. doi: 10.1021/jf047894h. - DOI - PubMed

[8] Hassimotto N.M., Genovese M.I., Lajolo F.M. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. J. Agric. Food Chem. 2005;53(8):2928–2935. doi: 10.1021/jf047894h. - DOI - PubMed

[9] Yan F., Polk D.B. Probiotics and immune health. Curr. Opin. Gastroenterol. 2011;27(6):496–501. doi: 10.1097/MOG.0b013e32834baa4d. - DOI - PMC - PubMed

[10] Yan F., Polk D.B. Probiotics and immune health. Curr. Opin. Gastroenterol. 2011;27(6):496–501. doi: 10.1097/MOG.0b013e32834baa4d. - DOI - PMC - PubMed

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Bioactive compounds and probiotics-a ray of hope in COVID-19 management

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Bioactive compounds and probiotics-a ray of hope in COVID-19 management

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