Deconstructing cancer with precision genome editing
- PMID: 38629716
- PMCID: PMC11088927
- DOI: 10.1042/BST20230984
Deconstructing cancer with precision genome editing
Abstract
Recent advances in genome editing technologies are allowing investigators to engineer and study cancer-associated mutations in their endogenous genetic contexts with high precision and efficiency. Of these, base editing and prime editing are quickly becoming gold-standards in the field due to their versatility and scalability. Here, we review the merits and limitations of these precision genome editing technologies, their application to modern cancer research, and speculate how these could be integrated to address future directions in the field.
Keywords: CRISPR; functional genomics; genetics; genome editing; genomics; mouse models.
© 2024 The Author(s).
Conflict of interest statement
The authors declare that there are no competing interests associated with the manuscript.
Figures
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