Evaluation of Safety and Beneficial Health Effects of the Human-Milk Strain Bifidobacterium breve DSM32583: An Infant Pilot Trial
- PMID: 38674825
- PMCID: PMC11053739
- DOI: 10.3390/nu16081134
Evaluation of Safety and Beneficial Health Effects of the Human-Milk Strain Bifidobacterium breve DSM32583: An Infant Pilot Trial
Abstract
Human milk promotes the growth of bifidobacteria in the infant gut. Adding bifidobacterial species to infant formula may contribute to increasing their presence in the gut of formula-fed infants. Therefore, the safety and anti-infectious effects of Bifidobacterium breve DSM32583, a breast milk isolate, were assessed in a pilot trial involving 3-month-old infants. The infants were randomly assigned to either the probiotic (PG) or the control (CG) groups. All the infants consumed the same formula, although it was supplemented with the strain (1 × 107 cfu/g of formula) in the PG. Overall, 160 infants (80 per group) finished the intervention. Infants in CG gained more weight compared to PG (p < 0.05), but the weights for age Z-scores at 6 months were within the normal distribution for this age group. The rates of infections affecting the gastrointestinal and respiratory tracts and antibiotic therapy were significantly lower in the PG. The bifidobacterial population and the level of short-chain fatty acids were higher (p < 0.05) in the fecal samples of PG infants. No adverse events related to formula consumption were observed. In conclusion, the administration of an infant formula with B. breve DSM32583 was safe and exerted potential beneficial effects on gut health.
Keywords: Bifidobacterium breve; bifidobacteria; infant formula; infections; probiotics; safety; short-chain fatty acids.
Conflict of interest statement
The authors declare no conflicts of interest. After the assay was completed, the strain was transferred to HiPP GmbH and Co. Vertrieb KG (Pfaffenhofen, Germany), an infant nutrition company. The company had no role in the study design, data collection, or analysis, but was involved in the writing of the manuscript.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/11053739/bin/nutrients-16-01134-g001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/11053739/bin/nutrients-16-01134-g002.gif)
Similar articles
-
Impact of synbiotics on gut microbiota during early life: a randomized, double-blind study.Sci Rep. 2021 Feb 11;11(1):3534. doi: 10.1038/s41598-021-83009-2. Sci Rep. 2021. PMID: 33574421 Free PMC article.
-
Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial.BMC Pediatr. 2019 Oct 21;19(1):361. doi: 10.1186/s12887-019-1753-7. BMC Pediatr. 2019. PMID: 31630683 Free PMC article. Clinical Trial.
-
Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome.Am J Clin Nutr. 2017 Nov;106(5):1274-1286. doi: 10.3945/ajcn.117.157529. Epub 2017 Sep 6. Am J Clin Nutr. 2017. PMID: 28877893 Clinical Trial.
-
The influence of the position of palmitate in infant formula triacylglycerols on health outcomes.Nutr Res. 2017 Aug;44:1-8. doi: 10.1016/j.nutres.2017.05.009. Epub 2017 May 17. Nutr Res. 2017. PMID: 28821313 Review.
-
Prebiotics in infant formulas.J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S76-9. doi: 10.1097/01.mcg.0000128927.91414.93. J Clin Gastroenterol. 2004. PMID: 15220664 Review.
References
-
- Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Mahony J., Belzer C., Delgado Palacio S., Arboleya Montes S., Mancabelli L., et al. The first microbial colonizers of the human gut: Composition activities, and health implications of the infant gut microbiota. Microbiol. Mol. Biol. Rev. 2017;81:e00036–e00117. doi: 10.1128/MMBR.00036-17. - DOI - PMC - PubMed
-
- Pannaraj P.S., Li F., Cerini C., Bender J.M., Yang S., Rollie A., Adisetiyo H., Zabih S., Lincez P.J., Bittinger K., et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA Pediatr. 2017;171:647–654. doi: 10.1001/jamapediatrics.2017.0378. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical