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Review
. 2023 Nov 30;9(4):431-445.
doi: 10.1002/ibra.12139. eCollection 2023 Winter.

Bibliometric analysis of cerebral organoids and diseases in the last 10 years

Bo-Yan Luo  1 , Ke-Qian Liu  1 , Ji-Sheng Fan  2
Affiliations
Review

Bibliometric analysis of cerebral organoids and diseases in the last 10 years

Bo-Yan Luo et al. Ibrain. .

Abstract

Cerebral organoids have emerged as a powerful tool for mirroring the brain developmental processes and replicating its unique physiology. This bibliometric analysis aims to delineate the burgeoning trends in the application of cerebral organoids in disease research and offer insights for future investigations. We screened all relevant literature from the Web of Science on cerebral organoids in disease research during the period 2013-2022 and analyzed the research trends in the field using VOSviewer, CiteSpace, and Scimago Graphica software. According to the search strategy, 592 articles were screened out. The United States of America (USA) was the most productive, followed by China and Germany. The top nine institutions in terms of the number of publications include Canada and the United States, with the University of California, San Diego (USA), having the highest number of publications. The International Journal of Molecular Sciences was the most productive journal. Knoblich, Juergen A., and Lancaster, Madeline A. published the highest number of articles. Keyword cluster analysis showed that current research trends focused more on induced pluripotent stem cells to construct organoid models of cerebral diseases and the exploration of their mechanisms and therapeutic modalities. This study provides a comprehensive summary and analysis of global research trends in the field of cerebral organoids in diseases. In the past decade, the number of high-quality papers in this field has increased significantly, and cerebral organoids provide hope for simulating nervous system diseases (such as Alzheimer's disease).

Keywords: bibliometric analysis; cerebral organoids; induced pluripotent stem cells; neurological diseases.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of literature identification. n represents the number of articles; WOSCC, Web of Science Core Collection. [Color figure can be viewed at wileyonlinelibrary.com]
Figure 2
Figure 2
Global trends and frequency of citation related to cerebral organoids and disease research from 2013 to 2022. [Color figure can be viewed at wileyonlinelibrary.com]
Figure 3
Figure 3
Contribution of countries/regions to the field of cerebral organoids and disease research. (A) World map showing the global distribution of cerebral organoids and disease research. Different countries are indicated by different colors based on the number of articles published. (B) Distribution and international cooperation of countries/regions involved in cerebral organoids and disease research. The thickness of the line reflects the frequency of the cooperation; the thicker the line, the stronger the cooperation. (C) Total number of publication counts, average citation per item, and H‐index of countries that contributed more than 10 publications in this field. (D) Growth trends in the publication count of the countries/regions that contributed more than 10 publications in the field of cerebral organoids and disease research from 2013 to 2022. [Color figure can be viewed at wileyonlinelibrary.com]
Figure 4
Figure 4
Contribution of institutions in the field of cerebral organoids and disease research. (A) Total number of publications counts, average citation per item, and H‐index of institutions that contributed a minimum of nine papers in this field. (B) Mapping of the coauthorship analysis among the top 55 most productive institutions in cerebral organoids and disease research according to VOSviewer. Each node represents an institution, and the node size indicates the number of publications. The connection between the nodes represents a coauthorship relationship, and the thickness of the lines indicates strength. [Color figure can be viewed at wileyonlinelibrary.com]
Figure 5
Figure 5
Contribution of authors in the field of cerebral organoid and disease research. (A) Total number of publication counts and average citation per item of authors who contributed at least five articles in this field. (B) Mapping of the coauthorship analysis among the authors who published at least one paper on cerebral organoids and disease research according to VOSviewer. Each node represents an institution, and the node size indicates the number of publications. The connection between the nodes represents a coauthorship relationship, and the thickness of the lines indicates strength (TLS). [Color figure can be viewed at wileyonlinelibrary.com]
Figure 6
Figure 6
Contribution of journals in the field of cerebral organoids and disease research. (A) Growth trends in the number of publications of the top nine productive journals in cerebral organoids and disease research from 2013 to 2022. (B) Dual‐map overlay of the journals on cerebral organoids and disease research generated by CiteSpace. The labels represent different research subjects covered by the journals. The citation journals are on the left side, while the other side of the map shows the cited journals. Different‐colored lines correspond to the different paths of references, beginning with the citation map and ending at the cited map. [Color figure can be viewed at wileyonlinelibrary.com]
Figure 7
Figure 7
Contribution of keywords in the field of cerebral organoids and disease research. (A) Keyword co‐occurrence analysis on cerebral organoids and disease research using VOS viewer. (B) Overlay visualization of the keyword co‐occurrence analysis. The purple nodes represent the keywords appearing earlier, whereas the yellow nodes show the recently appearing keywords. [Color figure can be viewed at wileyonlinelibrary.com]
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