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. 2024 May 15;16(19):24308-24320.
doi: 10.1021/acsami.4c02634. Epub 2024 Apr 30.

Superoxide Dismutase-Mimetic Polyphenol-Based Carbon Dots for Multimodal Bioimaging and Treatment of Atopic Dermatitis

Jeongmin Han  1 , Sumi Choi  1 , Jinwoo Hong  1 , Dayeong Gang  1 , Seunghoon Lee  1   2 , Kwangsoo Shin  3 , Junghyeon Ko  4 , Jeong-Uk Kim  4 , Nathaniel S Hwang  4   5 , Young-Hyeon An  4   5 , Minsu Gu  1 , Su-Hwan Kim  1
Affiliations

Superoxide Dismutase-Mimetic Polyphenol-Based Carbon Dots for Multimodal Bioimaging and Treatment of Atopic Dermatitis

Jeongmin Han et al. ACS Appl Mater Interfaces. .

Abstract

Polyphenols have been investigated for their potential to mitigate inflammation in the context of atopic dermatitis (AD). In this study, epigallocatechin-3-gallate (EGCG)-based carbon dots (EGCG@CDs) were developed to enhance transdermal penetration, reduce inflammation, recapitulate superoxide dismutase (SOD) activity, and provide antimicrobial effects for AD treatment. The water-soluble EGCG@CDs in a few nanometers size exhibit a negative zeta potential, making them suitable for effective transdermal penetration. The fluorescence properties, including an upconversion effect, make EGCG@CDs suitable imaging probes for both in vitro and in vivo applications. By mimicking the SOD enzyme, EGCG@CDs scavenge reactive oxygen species (ROS) and actively produce hydrogen peroxide through a highly catalytic capability toward the oxygen reduction reaction, resulting in the inhibition of bacterial growth. The enhanced antioxidant properties, high charge mobility, and various functional groups of EGCG@CDs prove effective in reducing intracellular ROS in an in vitro AD model. In the mouse AD model, EGCG@CDs incorporated into a hydrogel actively penetrated the epidermal layer, leading to ROS scavenging, reduced mast cell activation, and histological recovery of skin barriers. This research represents the versatile potential of EGCG@CDs in addressing AD and advancing tissue engineering.

Keywords: EGCG-based carbon dot; ROS scavenging; SOD; antimicrobial peptide; atopic dermatitis; intradermal delivery.

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