The role of natural products versus miRNA in renal cell carcinoma: implications for disease mechanisms and diagnostic markers
- PMID: 38691151
- DOI: 10.1007/s00210-024-03121-8
The role of natural products versus miRNA in renal cell carcinoma: implications for disease mechanisms and diagnostic markers
Abstract
Natural products are chemical compounds produced by living organisms. They are isolated and purified to determine their function and can potentially be used as therapeutic agents. The ability of some bioactive natural products to modify the course of cancer is fascinating and promising. In the past 50 years, there have been advancements in cancer therapy that have increased survival rates for localized tumors. However, there has been little progress in treating advanced renal cell carcinoma (RCC), which is resistant to radiation and chemotherapy. Oncogenes and tumor suppressors are two roles played by microRNAs (miRNAs). They are involved in important pathogenetic mechanisms like hypoxia and epithelial-mesenchymal transition (EMT); they control apoptosis, cell growth, migration, invasion, angiogenesis, and proliferation through target proteins involved in various signaling pathways. Depending on their expression pattern, miRNAs may identify certain subtypes of RCC or distinguish tumor tissue from healthy renal tissue. As diagnostic biomarkers of RCC, circulating miRNAs show promise. There is a correlation between the expression patterns of several miRNAs and the prognosis and diagnosis of patients with RCC. Potentially high-risk primary tumors may be identified by comparing original tumor tissue with metastases. Variations in miRNA expression between treatment-sensitive and therapy-resistant patients' tissues and serum allow for the estimation of responsiveness to target therapy. Our knowledge of miRNAs' function in RCC etiology has a tremendous uptick. Finding and validating their gene targets could have an immediate effect on creating anticancer treatments based on miRNAs. Several miRNAs have the potential to be used as biomarkers for diagnosis and prognosis. This review provides an in-depth analysis of the current knowledge regarding natural compounds and their modes of action in combating cancer. Also, this study aims to give information about the diagnostic and prognostic value of miRNAs as cancer biomarkers and their involvement in the pathogenesis of RCC.
Keywords: Diagnosis; Natural products, miRNA; Pathogenesis; Renal cell carcinoma (RCC).
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Similar articles
-
Molecular functions of microRNAs in colorectal cancer: recent roles in proliferation, angiogenesis, apoptosis, and chemoresistance.Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 15. doi: 10.1007/s00210-024-03076-w. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38619588 Review.
-
MicroRNAs Associated with Von Hippel-Lindau Pathway in Renal Cell Carcinoma: A Comprehensive Review.Int J Mol Sci. 2017 Nov 22;18(11):2495. doi: 10.3390/ijms18112495. Int J Mol Sci. 2017. PMID: 29165391 Free PMC article. Review.
-
Identification and validation of novel prognostic markers in Renal Cell Carcinoma.Dan Med J. 2017 Oct;64(10):B5339. Dan Med J. 2017. PMID: 28975890
-
MicroRNAs in the pathogenesis of renal cell carcinoma and their diagnostic and prognostic utility as cancer biomarkers.Int J Biol Markers. 2016 Feb 28;31(1):e26-37. doi: 10.5301/jbm.5000174. Int J Biol Markers. 2016. PMID: 26481440
-
miRNA and cancer; computational and experimental approaches.Curr Pharm Biotechnol. 2014;15(5):429. doi: 10.2174/138920101505140828161335. Curr Pharm Biotechnol. 2014. PMID: 25189575
References
-
- Al Serwi RH, Darwish SF, Mahran YF (2020) Growth hormone modulates the inflammatory and apoptotic pathways incorporated in fluorouracil-induced oral mucositis in rats. Egypt Dent J 66:327–336 - DOI
-
- Al-Warhi T, Sallam A-AM, Hemeda LR, El Hassab MA, Aljaeed N, Alotaibi OJ, Doghish AS, Noshy M, Eldehna WM, Ibrahim MH (2022) Identification of novel cyanopyridones and pyrido [2, 3-D] pyrimidines as anticancer agents with dual VEGFR-2/HER-2 inhibitory action: synthesis, biological evaluation and molecular docking studies. Pharmaceuticals 15:1262 - PubMed - PMC - DOI
-
- Anwar MJ, Altaf A, Imran M, Amir M, Alsagaby SA, Abdulmonem WA, Mujtaba A, El-Ghorab AH, Ghoneim MM, Hussain M (2023) Anti-cancer perspectives of resveratrol: a comprehensive review. Food Hydrocolloids 34:2265686
Publication types
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous