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Review
. 2024 May 7.
doi: 10.1038/s41366-024-01530-6. Online ahead of print.

Obesity: a 100 year perspective

George A Bray  1
Affiliations
Review

Obesity: a 100 year perspective

George A Bray. Int J Obes (Lond). .

Abstract

This review has examined the scientific basis for our current understanding of obesity that has developed over the past 100 plus years. Obesity was defined as an excess of body fat. Methods of establishing population and individual changes in levels of excess fat are discussed. Fat cells are important storage site for excess nutrients and their size and number affect the response to insulin and other hormones. Obesity as a reflection of a positive fat balance is influenced by a number of genetic and environmental factors and phenotypes of obesity can be developed from several perspectives, some of which have been elaborated here. Food intake is essential for maintenance of human health and for the storage of fat, both in normal amounts and in obesity in excess amounts. Treatment approaches have taken several forms. There have been numerous diets, behavioral approaches, along with the development of medications.. Bariatric/metabolic surgery provides the standard for successful weight loss and has been shown to have important effects on future health. Because so many people are classified with obesity, the problem has taken on important public health dimensions. In addition to the scientific background, obesity through publications and organizations has developed its own identity. While studying the problem of obesity this reviewer developed several aphorisms about the problem that are elaborated in the final section of this paper.

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References

    1. Quetelet, Adolphe Sur l’homme et le developpement de ses facultes, ou essai de physique sociale; Paris: Bachelier, 1835 (Transl of L-A-J. A Treatise on Man and the Development of His Faculties. IN: Bray GA. The Battle of the Bulge: A History of Obesity Research. Pittsburgh: Dorrance Publishing, 2007 pp 423-36.
    1. Bray GA. Quetelet: quantitative medicine. Obes Res. 1994;2:68–71. - PubMed - DOI
    1. Bray GA. Beyond BMI. Nutrients. 2023;15:2254. - PubMed - PMC - DOI
    1. Flegal KM. Use and misuse of BMI categories. AMA J Ethics. 2023;25:E550–8. - PubMed - DOI
    1. Keys A, Fidanza F, Karvonen MJ, Kimura N, Taylor HL. Indices of relative weight and obesity. J Chr Diseases. 1972;25:329–43. - DOI

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