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. 2024 May 15.
doi: 10.1007/s12094-024-03497-2. Online ahead of print.

SEOM-GEM clinical guidelines for cutaneous melanoma (2023)

Iván Márquez-Rodas  1 , Eva Muñoz Couselo  2 , Juan F Rodríguez Moreno  3 , Ana Mª Arance Fernández  4 , Miguel Ángel Berciano Guerrero  5 , Begoña Campos Balea  6 , Luis de la Cruz Merino  7 , Enrique Espinosa Arranz  8 , Almudena García Castaño  9 , Alfonso Berrocal Jaime  10
Affiliations

SEOM-GEM clinical guidelines for cutaneous melanoma (2023)

Iván Márquez-Rodas et al. Clin Transl Oncol. .

Abstract

Cutaneous melanoma incidence is rising. Early diagnosis and treatment administration are key for increasing the chances of survival. For patients with locoregional advanced melanoma that can be treated with complete resection, adjuvant-and more recently neoadjuvant-with targeted therapy-BRAF and MEK inhibitors-and immunotherapy-anti-PD-1-based therapies-offer opportunities to reduce the risk of relapse and distant metastases. For patients with advanced disease not amenable to radical treatment, these treatments offer an unprecedented increase in overall survival. A group of medical oncologists from the Spanish Society of Medical Oncology (SEOM) and Spanish Multidisciplinary Melanoma Group (GEM) has designed these guidelines, based on a thorough review of the best evidence available. The following guidelines try to cover all the aspects from the diagnosis-clinical, pathological, and molecular-staging, risk stratification, adjuvant therapy, advanced disease therapy, and survivor follow-up, including special situations, such as brain metastases, refractory disease, and treatment sequencing. We aim help clinicians in the decision-making process.

Keywords: Immunotherapy; Melanoma; Staging; Targeted therapy.

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