Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Sep 15;28(2):143-50.
doi: 10.1016/0304-3835(85)90069-2.

Epidermal growth factor stimulates the growth of A431 tumors in athymic mice

E Ginsburg, B K Vonderhaar

Epidermal growth factor stimulates the growth of A431 tumors in athymic mice

E Ginsburg et al. Cancer Lett. .

Abstract

Growth of the human epidermoid carcinoma cell line A431 in vitro is stimulated by low concentrations of epidermal growth factor (EGF; 0.1-10 pM) and inhibited by high concentrations (0.1-10 nM). This cell also grows as a solid tumor in female athymic mice. Sustained high levels of EGF in vivo can be achieved by the administration of testosterone to female mice via a cholesterol-based pellet inserted subcutaneously. This chronic elevation of EGF levels (serum concentration = 90 ng/ml), however, does not affect growth of the tumor. In contrast, low levels of the growth factor (0.5 micrograms/g body wt by injection 5 times/week; serum concentration = 8.25 ng/ml) stimulate growth of the tumor. These data suggest that the mechanism(s) involved in the inhibition of A431 cell growth by EGF in vitro does not function in vivo and the physiologically significant effect of EGF in vivo is growth promotion.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources

-