Incidence of Thrombosis in COVID-19 Patients Compared to Non-COVID-19 Sepsis Patients in the Intensive Care Unit

doi:10.3390/jcm13102974

. 2024 May 18;13(10):2974.

doi: 10.3390/jcm13102974.

Incidence of Thrombosis in COVID-19 Patients Compared to Non-COVID-19 Sepsis Patients in the Intensive Care Unit

Affiliations

¹ Department of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL 33606, USA.
² Division of Pediatric Cardiology, Texas Children's Hospital, Houston, TX 77030, USA.
³ Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
⁴ Department of Hematology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
⁵ Department of Hematology and Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
⁶ Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33606, USA.

PMID: 38792515
PMCID: PMC11121895
DOI: 10.3390/jcm13102974

Incidence of Thrombosis in COVID-19 Patients Compared to Non-COVID-19 Sepsis Patients in the Intensive Care Unit

Sherri Huang et al. J Clin Med. 2024.

. 2024 May 18;13(10):2974.

doi: 10.3390/jcm13102974.

Authors

Affiliations

¹ Department of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL 33606, USA.
² Division of Pediatric Cardiology, Texas Children's Hospital, Houston, TX 77030, USA.
³ Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
⁴ Department of Hematology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
⁵ Department of Hematology and Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
⁶ Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33606, USA.

PMID: 38792515
PMCID: PMC11121895
DOI: 10.3390/jcm13102974

Abstract

Background/Objectives: The hypercoagulable state associated with COVID-19 infection is associated with adverse outcomes and mortality. Studies have also demonstrated high rates of venous thromboembolism (VTE) events among patients with sepsis. We aimed to evaluate how the increase in thrombotic events in critically ill patients with COVID-19 infection compares to that of critically ill patients with non-COVID-19 sepsis. Methods: A chart review was performed of patients 18 years or older admitted to the intensive care unit (ICU) at Tampa General Hospital between 1 January 2020 and 31 December 2020 diagnosed with COVID-19 or sepsis secondary to other pathogens. Non-COVID-19 sepsis patients and COVID-19 patients were propensity-matched 3:1 on the Charlson Comorbidity Index. Multivariate analyses adjusting for confounding were conducted to report odds ratio (OR) and 95% confidence intervals (95% CIs) of predictors for thrombotic events and overall mortality. Results: After propensity score matching, 492 sepsis patients and 164 COVID-19 patients were included in the analysis. COVID-19 patients were significantly older (p = 0.021) and showed higher BMI (p < 0.001) than sepsis patients. COVID-19 patients did not show significantly higher odds of thrombosis after adjustment for confounders (OR 0.85, 95% CI 0.42-1.72), but had significantly lower odds of mortality than sepsis patients (OR 0.33, 95% CI 0.16-0.66). Conclusions: Our results suggest that further study is required to lower the rate of VTE in COVID-19 and non-COVID-19 sepsis patients admitted to the ICU; it is also reasonable to consider similar thromboembolism practices between these two patient groups.

Keywords: COVID-19; intensive care unit; sepsis; venous thromboembolism.

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Conflict of interest statement

All authors except M.J. certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. M.J. is a consultant for Novartis and Sanofi. No funds, grants, or other support was received.

References

1. World Health Organization WHO Coronavirus (COVID-19) Dashboard. [(accessed on 30 May 2023)]. Available online: https://covid19.who.int/
1. Li C., He Q., Qian H., Liu J. Overview of the pathogenesis of COVID-19 (Review) Exp. Ther. Med. 2021;22:1011. doi: 10.3892/etm.2021.10444. - DOI - PMC - PubMed
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1. Number of COVID-19 Patients in Intensive Care (ICU) [(accessed on 1 July 2022)]. Available online: https://ourworldindata.org/grapher/current-covid-patients-icu.
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[1] World Health Organization WHO Coronavirus (COVID-19) Dashboard. [(accessed on 30 May 2023)]. Available online: https://covid19.who.int/

[2] World Health Organization WHO Coronavirus (COVID-19) Dashboard. [(accessed on 30 May 2023)]. Available online: https://covid19.who.int/

[3] Li C., He Q., Qian H., Liu J. Overview of the pathogenesis of COVID-19 (Review) Exp. Ther. Med. 2021;22:1011. doi: 10.3892/etm.2021.10444. - DOI - PMC - PubMed

[4] Li C., He Q., Qian H., Liu J. Overview of the pathogenesis of COVID-19 (Review) Exp. Ther. Med. 2021;22:1011. doi: 10.3892/etm.2021.10444. - DOI - PMC - PubMed

[5] Chan J.F., Kok K.H., Zhu Z., Chu H., To K.K., Yuan S., Yuen K.Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg. Microbes Infect. 2020;9:221–236. doi: 10.1080/22221751.2020.1719902. - DOI - PMC - PubMed

[6] Chan J.F., Kok K.H., Zhu Z., Chu H., To K.K., Yuan S., Yuen K.Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg. Microbes Infect. 2020;9:221–236. doi: 10.1080/22221751.2020.1719902. - DOI - PMC - PubMed

[7] Number of COVID-19 Patients in Intensive Care (ICU) [(accessed on 1 July 2022)]. Available online: https://ourworldindata.org/grapher/current-covid-patients-icu.

[8] Number of COVID-19 Patients in Intensive Care (ICU) [(accessed on 1 July 2022)]. Available online: https://ourworldindata.org/grapher/current-covid-patients-icu.

[9] Navas-Martin S.R., Weiss S. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J. Neurovirol. 2004;10:75–85. doi: 10.1080/13550280490280292. - DOI - PMC - PubMed

[10] Navas-Martin S.R., Weiss S. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J. Neurovirol. 2004;10:75–85. doi: 10.1080/13550280490280292. - DOI - PMC - PubMed

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Incidence of Thrombosis in COVID-19 Patients Compared to Non-COVID-19 Sepsis Patients in the Intensive Care Unit

Affiliations

Incidence of Thrombosis in COVID-19 Patients Compared to Non-COVID-19 Sepsis Patients in the Intensive Care Unit

Authors

Affiliations

Abstract

Conflict of interest statement

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Abstract

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