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Case Reports
. 2024 Apr 26;16(4):e59058.
doi: 10.7759/cureus.59058. eCollection 2024 Apr.

Gender Differences in the Evaluation and Management of New Acute CHF Due to ATTRwt Cardiac Amyloidosis

Michael Fragner  1 , Jude Elsaygh  1 , Sudarshan S Srivats  2 , Kevin Pink  1
Affiliations
Case Reports

Gender Differences in the Evaluation and Management of New Acute CHF Due to ATTRwt Cardiac Amyloidosis

Michael Fragner et al. Cureus. .

Abstract

Cardiac amyloidosis can be grouped into two main categories: immunoglobulin light chain (AL) and transthyretin (hATTR or hereditary and ATTRwt or wild type). Cardiac infiltration of misfolded proteins can lead to significant infiltrative processes and subsequent heart failure. Diagnosis of ATTRwt heavily relies on clinical suspicion, as it typically appears later in life and is limited to the heart. It is routinely reported that ATTRwt significantly affects males more than females; however, older patients diagnosed with ATTRwt and those diagnosed at autopsy are significantly more likely to be female. Earlier, a more precise diagnosis in females could detect disease at an earlier stage and expedite treatment.

Keywords: adult cardiac disease; amyloid; cardiac amyloid; gender differences; transthyretin amyloid cardiomyopathy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Transthoracic echocardiogram
Parasternal long axis view (A) and parasternal short axis view (B) demonstrating moderate concentric left ventricular hypertrophy, a moderately dilated left ventricle, and an interventricular septal diameter of 1.2 cm.
Figure 2
Figure 2. Technetium-99m pyrophosphate scan
The heart-to-contralateral lung (H/CL) ratio using region of interest (ROI) was 1.55, indicating focal myocardial uptake of technetium-99m pyrophosphate.
Figure 3
Figure 3. Single-photon emission computed tomography (SPECT) imaging of the myocardium
Three-dimensional display confirming uptake of radioactive tracer in the myocardium.
See this image and copyright information in PMC

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