Changes in vessel density patterns assessed with OCTA in patients with diabetic macular edema treated with anti-VEGF therapy
- PMID: 38802603
- DOI: 10.1007/s00592-024-02290-5
Changes in vessel density patterns assessed with OCTA in patients with diabetic macular edema treated with anti-VEGF therapy
Abstract
Aims: To determine the presence of sectoral changes in vessel density (VD) patterns induced by vascular endothelial growth factor inhibitors (anti-VEGF) in patients with diabetic macular edema (DME) using optical coherence tomography angiography (OCTA).
Methods: Prospective, interventional study. A total of 43 patients (63 eyes) were initially enrolled in the study. We performed swept source (SS) OCT and sectorial OCTA measurement to determine parafoveal VD at baseline and after six months of anti-VEGF treatment. In the locations with statistically significant differences in VD between baseline and month 6, we performed univariate and multivariate analyses to determine which, if any, of the baseline variables were associated with the observed changes.
Results: A total of 34 patients (48 eyes) were included in the final analysis. Mean VD decreased from baseline to month 6 (from 45.2 (± 3.5) to 44.6 (± 3.2) % in the SCP and from 50 (± 3.3) to 49 (± 3.9) % in the DCP). The only significant changes in VD were observed in the nasal sector of the deep capillary plexus, with a decrease of 2.9% (p = 0.001). On univariate and multivariate analyses, the only variable significantly associated with changes in VD in the nasal sector after 6 months of treatment was baseline VD in the same sector.
Conclusions: Anti-VEGF therapy has a small impact on VD values over time. These variations observed after treatment seems to be related to changes over areas of vascular anomalies and displaced vessels adjacent to cystic areas, with no significant changes over ischemic areas. No correlation was observed between this trend and other clinical baseline features.
Keywords: Anti-VEGF inhibitors; Diabetic macular edema; Optical coherence tomography angiography; Vessel density.
© 2024. The Author(s).
Similar articles
-
Correlation between Topographic Vessel Density and Retinal Thickness Changes in Patients with Diabetic Macular Edema Treated with Anti-VEGF Therapy: Is It a Suitable OCTA Biomarker?J Pers Med. 2023 Dec 16;13(12):1718. doi: 10.3390/jpm13121718. J Pers Med. 2023. PMID: 38138945 Free PMC article.
-
Optical coherence tomography angiography analysis of macular vessel density before and after anti-VEGF therapy in eyes with diabetic retinopathy.Int Ophthalmol. 2019 Oct;39(10):2361-2371. doi: 10.1007/s10792-019-01076-x. Epub 2019 May 22. Int Ophthalmol. 2019. PMID: 31119505
-
OCT Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study.Ophthalmology. 2019 Dec;126(12):1675-1684. doi: 10.1016/j.ophtha.2019.06.016. Epub 2019 Jun 26. Ophthalmology. 2019. PMID: 31358386
-
Vessel Density Changes on Optical Coherence Tomography Angiography after Vascular Endothelial Growth Factor Inhibitor Treatment for Diabetic Macular Edema.Turk J Ophthalmol. 2020 Dec 29;50(6):343-350. doi: 10.4274/tjo.galenos.2020.81592. Turk J Ophthalmol. 2020. PMID: 33389934 Free PMC article.
-
Evaluation of Posterior Ocular Blood Flow in Diabetic Retinopathy Patients Without Macular Edema Using Optical Coherence Tomography Angiography.Photodiagnosis Photodyn Ther. 2023 Dec;44:103777. doi: 10.1016/j.pdpdt.2023.103777. Epub 2023 Sep 3. Photodiagnosis Photodyn Ther. 2023. PMID: 37669724 Review.
References
-
- Hsieh YT, Alam MN, Le D et al (2019) OCT angiography biomarkers for predicting visual outcomes after ranibizumab treatment for diabetic macular edema. Ophthalmol Retina 3(10):826–834. https://doi.org/10.1016/j.oret.2019.04.027 - DOI - PubMed - PMC
-
- Perais J, Agarwal R, Evans JR et al (2023) Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy. Cochrane Database Syst Rev. 2(2):CD013775. https://doi.org/10.1002/14651858.CD013775.pub2 - DOI - PubMed
-
- Or C, Sabrosa AS, Sorour O, Arya M, Waheed N (2018) Use of OCTA, FA, and ultra-widefield imaging in quantifying retinal ischemia: a review. Asia Pac J Ophthalmol (Phila) 7(1):46–51. https://doi.org/10.22608/APO.201812 - DOI - PubMed - PMC
-
- Adhi M, Brewer E, Waheed NK, Duker JS (2013) Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography. JAMA Ophthalmol 131(10):1267–1274. https://doi.org/10.1001/jamaophthalmol.2013.4321 - DOI - PubMed - PMC
-
- Khadamy J, AbriAghdam K, Falavarjani KG (2018) An update on optical coherence tomography angiography in diabetic retinopathy. J Ophthalmic Vis Res 13(4):487–497. https://doi.org/10.4103/jovr.jovr_57_18 - DOI - PubMed - PMC
LinkOut - more resources
Full Text Sources
Miscellaneous