Role of marine natural products in the development of antiviral agents against SARS-CoV-2: potential and prospects
- PMID: 38827130
- PMCID: PMC11136918
- DOI: 10.1007/s42995-023-00215-9
Role of marine natural products in the development of antiviral agents against SARS-CoV-2: potential and prospects
Abstract
A novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has surfaced and caused global concern owing to its ferocity. SARS-CoV-2 is the causative agent of coronavirus disease 2019; however, it was only discovered at the end of the year and was considered a pandemic by the World Health Organization. Therefore, the development of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently required. Numerous naturally occurring bioactive substances have been studied in the clinical setting for diverse disorders. The intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic compounds. Marine natural products (MNPs) have received increased attention in the development of novel drugs owing to their high diversity and availability. Therefore, this review article investigates the infection and replication mechanisms, including the function of the SARS-CoV-2 genome and structure. Furthermore, we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.
Supplementary information: The online version contains supplementary material available at 10.1007/s42995-023-00215-9.
Keywords: Drug targets; Inhibitors; Marine natural products; SARS-CoV-2.
© Ocean University of China 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Conflict of interest statement
Conflict of interestThe authors declare no conflict of interest. Author You-Jin Jeon is one of the Editorial Board Members, but he was not involved in the journal’s review of, or decision related to, this manuscript.
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