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. 2024 Jun 25;19(1):53.
doi: 10.1007/s11657-024-01402-6.

Hip fracture rate and osteoporosis treatment in Ontario: A population-based retrospective cohort study

Affiliations

Hip fracture rate and osteoporosis treatment in Ontario: A population-based retrospective cohort study

Hajar AbuAlrob et al. Arch Osteoporos. .

Abstract

This population-based study analyzes hip fracture and osteoporosis treatment rates among older adults, stratified by place of residence prior to fracture. Hip fracture rates were higher among older adults living in the community and discharged to long-term care (LTC) after fracture, compared to LTC residents and older adults living in the community. Only 23% of LTC residents at high fracture risk received osteoporosis treatment.

Purpose: This population-based study examines hip fracture rate and osteoporosis management among long-term care (LTC) residents > 65 years of age compared to community-dwelling older adults at the time of fracture and admitted to LTC after fracture, in Ontario, Canada.

Methods: Healthcare utilization and administrative databases were linked using unique, encoded identifiers from the ICES Data Repository to estimate hip fractures (identified using the Public Health Agency of Canada algorithm and International Classification of Diseases (ICD)-10 codes) and osteoporosis management (pharmacotherapy) among adults > 66 years from April 1, 2014 to March 31, 2018. Sex-specific and age-standardized rates were compared by pre-fracture residency and discharge location (i.e., LTC to LTC, community to LTC, or community to community). Fracture risk was determined using the Fracture Risk Scale (FRS).

Results: At baseline (2014/15), the overall age-standardized hip fracture rate among LTC residents was 223 per 10,000 person-years (173 per 10,000 females and 157 per 10,000 males), 509 per 10,000 person-years (468 per 10,000 females and 320 per 10,000 males) among the community to LTC cohort, and 31.5 per 10,000 person-years (43.1 per 10,000 females and 25.6 per 10,000 males). During the 5-year observation period, the overall annual average percent change (APC) for hip fracture increased significantly in LTC (AAPC = + 8.6 (95% CI 5.0 to 12.3; p = 0.004) compared to the community to LTC group (AAPC = + 2.5 (95% CI - 3.0 to 8.2; p = 0.248)) and the community-to-community cohort (AAPC - 3.8 (95% CI - 6.7 to - 0.7; p = 030)). However, hip fracture rate remained higher in the community to LTC group over the study period. There were 33,594 LTC residents identified as high risk of fracture (FRS score 4 +), of which 7777 were on treatment (23.3%).

Conclusion: Overall, hip fracture rates have increased in LTC and among community-dwelling adults admitted to LTC after fracture. However, hip fracture rates among community-dwelling adults have decreased over time. A non-significant increase in osteoporosis treatment rates was observed among LTC residents at high risk of fracture (FRS4 +). Residents in LTC are at very high risk for fracture and require individualized based on goals of care and life expectancy.

Keywords: Fragility fracture; Long-term care; Osteoporosis; Post-fracture care; Real-world data.

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Conflict of interest statement

The authors Hajar AbuAlrob declare that they have no conflict of interest, George Ioannidis declares that they have no conflict of interest, Susan Jaglal declares that they have no conflict of interest Andrew Costa declares that they have no conflict of interest, Lauren E. Grifith declares that they have no conflict of interest, Lehana Thabane declares that they have no conflict of interest, Cathy Cameron declares that they have no conflict of interest, Loretta Hillier declares that they have no conflict of interest, and Arthur Lau, declares that they have no conflict of interest. Jonathan D. Adachi received Honoraria from Amgen and Paladin; advisory board Amgen, Paladin (speaker), Gilead (speaker); clinical trials Amgen and Radius. Alexandra Papaioannou received Amgen grants/Research support Amgen, Ontario College of Family Physicians Honoraria/Consulting fees; Amgen, Paladin Speakers Bureau; Other support from McMaster University, Osteoporosis Canada, CABHI, Ontario College of Family Physicians, CIHR.

Figures

Fig. 1
Fig. 1
A Cohort flow diagram; b Study cohort stratified by place of residence before and after fracture discharge
Fig. 2
Fig. 2
Fracture risk scale (FRS) decision tree analysis [7]
Fig. 3
Fig. 3
A) Overall age-standardized hip fracture rate (per 10,000 person-years) from 2014/15 to 2018/19 among cohorts. b) APC across subgroups by sex, age, settings from 2014/15 to 2018/19 among cohorts, APC across subgroups by sex, age, settings
Fig. 3
Fig. 3
A) Overall age-standardized hip fracture rate (per 10,000 person-years) from 2014/15 to 2018/19 among cohorts. b) APC across subgroups by sex, age, settings from 2014/15 to 2018/19 among cohorts, APC across subgroups by sex, age, settings

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