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. 2024 Jul 12;14(1):16098.
doi: 10.1038/s41598-024-67127-1.

Elevated TyG index is associated with increased risk of vitamin D deficiency among elderly patients with type 2 diabetes

Qunyan Xiang  1   2 , Hu Xu  1   3 , Youshou Liu  1   2 , Wu Huang  4   5
Affiliations

Elevated TyG index is associated with increased risk of vitamin D deficiency among elderly patients with type 2 diabetes

Qunyan Xiang et al. Sci Rep. .

Abstract

Vitamin D deficiency (VDD) is associated with increased risk of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We aimed to investigate the association between the triglyceride-glucose (TyG) index that represents IR and VDD in elderly patients with T2DM. We enrolled 572 elderly participants with T2DM in this study. TyG index was calculated as ln [fasting triglyceride (TG, mg/dL) × fasting blood glucose (mg/dL)/2]. Serum 25-hydroxyvitamin D [25(OH)D] level below 50 nmol/L was defined as VDD. The association between the TyG index and the VDD risk was evaluated by multivariate logistic regression analysis. We observed a significant decreased 25(OH)D level with the increase of the TyG index in elderly diabetic patients, and a negative correlation between the TyG index and 25(OH)D level. The participants in the highest TyG quartile had a 2.40-fold higher risk of VDD than those in the lowest TyG index quartile [OR 2.40; 95% CI 1.47-3.92; P < 0.001]. The association persisted after adjustments for age, sex, smoking, obesity, insulin therapy, hypoglycemic agents' medication, and some biochemical parameters. TyG index may be involved in the pathophysiology of VDD, which could be a predictor for VDD in elderly diabetic patients.

Keywords: Elderly people; Triglyceride-glucose index; Type 2 diabetes mellitus; Vitamin D deficiency.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart of the participants enrolled in this study. The flowchart presented the procedure for inclusion and exclusion of the participants enrolled in the present study.
Figure 2
Figure 2
Association between the TyG index and serum 25(OH)D level. (A) Comparisons of 25(OH)D level among the quartiles of the TyG index. (B) Spearman’s correlation between the TyG index and 25(OH)D level. *P < 0.05, ***P < 0.001, compared with the Q1 quartile of the TyG index. ns no significant, TyG index triglyceride-glucose index, 25(OH)D 25-hydroxyvitamin D.
Figure 3
Figure 3
VDD prevalence among the TyG index quartiles. VDD vitamin D deficiency, TyG index triglyceride-glucose index.
See this image and copyright information in PMC

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