Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring
- PMID: 4066048
- DOI: 10.1007/BF00396596
Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring
Abstract
Internal stress of aromatic amines has so far been evaluated by their determination in blood or urine and by the degree of methemoglobin formation. Animal experiments have shown that these materials can form adducts and conjugates with proteins and nucleic acids. Our investigations show that these processes can also occur in human metabolism. For this the degree of such a formation of protein conjugates depends on an individually different potential for acetylation. In a positive sense it influences the magnitude and the rate of renal excretion of aminoaromates and their conjugates and metabolites formed by this metabolism. In contrast, only free nonacetylated aminoaromates can lead to the formation of conjugates with hemoglobin. These aminoaromates or their metabolites can then be detected quantitatively in intact erythrocytes during their lifespan. The degree of this protein conjugate formation correlates inversely with the magnitude of the acetylation potential depending on the availability of free non-acetylated aminoaromates. According to these results a clearer assessment of past stress or the presence of strain can be obtained with Biological Monitoring by a single determination of such hemoglobin adducts rather than by the traditional quantitative determination of aminoaromates or their metabolites in blood and/or urine or the methemoglobin concentration.
Similar articles
-
Biomonitoring of aromatic amines II: Hemoglobin binding of some monocyclic aromatic amines.Arch Toxicol. 1988;62(2-3):110-5. doi: 10.1007/BF00570128. Arch Toxicol. 1988. PMID: 3196145
-
Biomonitoring of aromatic amines V: acetylation and deacetylation in the metabolic activation of aromatic amines as determined by haemoglobin binding.Arch Toxicol. 1998 Jul-Aug;72(8):499-504. doi: 10.1007/s002040050534. Arch Toxicol. 1998. PMID: 9765065
-
Biomonitoring of aromatic amines and alkylating agents by measuring hemoglobin adducts.Int Arch Occup Environ Health. 1988;60(3):151-5. doi: 10.1007/BF00378690. Int Arch Occup Environ Health. 1988. PMID: 3384479
-
Molecular dosimetry of aromatic amines in human populations.Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):17-21. doi: 10.1289/ehp.94102s617. Environ Health Perspect. 1994. PMID: 7889842 Free PMC article. Review.
-
[Erythrocyte, plasma and substitute hemoglobins facing physiological oxidizing and reducing agents].Ann Biol Clin (Paris). 1998 Sep-Oct;56(5):545-56. Ann Biol Clin (Paris). 1998. PMID: 9769507 Review. French.
Cited by
-
Mode of action-based risk assessment of genotoxic carcinogens.Arch Toxicol. 2020 Jun;94(6):1787-1877. doi: 10.1007/s00204-020-02733-2. Epub 2020 Jun 15. Arch Toxicol. 2020. PMID: 32542409 Free PMC article. Review.
-
Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?Am J Hum Genet. 1997 Feb;60(2):265-71. Am J Hum Genet. 1997. PMID: 9012398 Free PMC article. Review. No abstract available.
-
Biomonitoring of urinary aromatic amines and arylamine hemoglobin adducts in exposed workers and nonexposed control persons.Int Arch Occup Environ Health. 1995;68(1):36-43. doi: 10.1007/BF01831631. Int Arch Occup Environ Health. 1995. PMID: 8847111
-
Biological monitoring for occupational exposures to o-toluidine and aniline.Int Arch Occup Environ Health. 1993;65(1 Suppl):S115-8. doi: 10.1007/BF00381320. Int Arch Occup Environ Health. 1993. PMID: 8406905
-
Hemoglobin adducts of N-substituted aryl compounds in exposure control and risk assessment.Environ Health Perspect. 1993 Mar;99:65-9. doi: 10.1289/ehp.939965. Environ Health Perspect. 1993. PMID: 8319661 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Miscellaneous