Multiple forms of cytochrome P450 in the microsomal monooxygenase system
- PMID: 579981
- DOI: 10.1007/BF00343274
Multiple forms of cytochrome P450 in the microsomal monooxygenase system
Abstract
The microsomal monooxygenase system is characterized by its broad substrate specificity which includes endogenous substrates as well as lipophilic drugs and chemicals. From in vitro investigations it was known that the relative reactivities and the pattern of products varied greatly with species, sex, age, diet or pretreatment with drugs of the animal. The suggestion that this was possibly due to a variety of cytochrome P450 enzymes rather than a single monooxygenase was recently confirmed by the isolation of several cytochrome P450 species with different although overlapping substrate specificities. In view of the consequences of a genetic and environment-dependent pattern on monooxygenases for drug metabolism and drug-mediated toxicity the methods of a quantitative assessment of the various forms are discussed.
Similar articles
-
Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.J Pharmacol Exp Ther. 1997 Feb;280(2):966-73. J Pharmacol Exp Ther. 1997. PMID: 9023313
-
Cytochrome P450 species involved in the metabolism of quinoline.Carcinogenesis. 1996 Sep;17(9):1989-96. doi: 10.1093/carcin/17.9.1989. Carcinogenesis. 1996. PMID: 8824525
-
Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.Arch Biochem Biophys. 1994 Jun;311(2):342-9. doi: 10.1006/abbi.1994.1246. Arch Biochem Biophys. 1994. PMID: 8203896
-
Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases.Biochem Biophys Res Commun. 2005 Dec 9;338(1):331-6. doi: 10.1016/j.bbrc.2005.08.190. Epub 2005 Sep 2. Biochem Biophys Res Commun. 2005. PMID: 16157296 Review.
-
Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.Expert Opin Drug Metab Toxicol. 2011 May;7(5):543-58. doi: 10.1517/17425255.2011.562194. Epub 2011 Mar 12. Expert Opin Drug Metab Toxicol. 2011. PMID: 21395496 Free PMC article. Review.
Cited by
-
Molecular genetics of cytochrome P450 IID. Anomalies of drug metabolism.Clin Rev Allergy Immunol. 1995 Fall;13(3):211-21. doi: 10.1007/BF02771762. Clin Rev Allergy Immunol. 1995. PMID: 8535928 Review. No abstract available.
-
The metabolism of 7-ethoxycoumarin in primary maintenance cultures of adult rat hepatocytes.Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):85-90. doi: 10.1007/BF00500307. Naunyn Schmiedebergs Arch Pharmacol. 1980. PMID: 7366743
-
Defective oxidation of drugs: pharmacokinetic and therapeutic implications.Clin Pharmacokinet. 1982 Jan-Feb;7(1):1-22. doi: 10.2165/00003088-198207010-00001. Clin Pharmacokinet. 1982. PMID: 7042170 Review. No abstract available.
-
A new animal model for the study of cutaneous drug-metabolizing enzymes.Arch Dermatol Res. 1981;270(3):367-9. doi: 10.1007/BF00403942. Arch Dermatol Res. 1981. PMID: 6973956 No abstract available.
-
Ontogenetic variation in rat liver, lung and kidney monooxygenase induction by low doses of benzo(A)pyrene and cigarette-smoke condensate.Br J Cancer. 1981 Dec;44(6):902-10. doi: 10.1038/bjc.1981.290. Br J Cancer. 1981. PMID: 6275873 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
