doi: 10.1016/s0140-6736(83)92084-6.
Forskolin lowers intraocular pressure in rabbits, monkeys, and man
- PMID: 6132271
- DOI: 10.1016/s0140-6736(83)92084-6
Item in Clipboard
Forskolin lowers intraocular pressure in rabbits, monkeys, and man
Lancet.
.
Abstract
Topical ocular application of forskolin, a diterpene that increases intracellular cyclic adenosine monophosphate by stimulating adenylate cyclase directly without cell surface mediation, lowered intraocular pressure (IOP) in rabbits, monkeys, and volunteers who were free from eye disease. In man 50 microliters of a topical suspension of 1% forskolin significantly lowered IOP in 1 h, the effect reaching a peak at 2 h but remaining significant for at least 5 h. Outflow pressure fell by 70% on average. Forskolin and its analogues represent a new class of drugs active against glaucoma which differ in their molecular actions from any previously used drug.
Similar articles
-
Forskolin: upcoming antiglaucoma molecule.J Postgrad Med. 2012 Jul-Sep;58(3):199-202. doi: 10.4103/0022-3859.101396. J Postgrad Med. 2012. PMID: 23023353 Review.
-
Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator.Exp Eye Res. 1984 Dec;39(6):745-9. doi: 10.1016/0014-4835(84)90073-3. Exp Eye Res. 1984. PMID: 6542866 Clinical Trial.
-
Forskolin lowers intraocular pressure by reducing aqueous inflow.Invest Ophthalmol Vis Sci. 1984 Mar;25(3):268-77. Invest Ophthalmol Vis Sci. 1984. PMID: 6538189
-
The adenylate cyclase receptor complex and aqueous humor formation.Yale J Biol Med. 1984 May-Jun;57(3):283-300. Yale J Biol Med. 1984. PMID: 6093393 Free PMC article. Review.
-
Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium.Am J Ophthalmol. 1985 Jul 15;100(1):194-8. doi: 10.1016/s0002-9394(14)75005-6. Am J Ophthalmol. 1985. PMID: 2990214
Cited by
-
Optic Nerve Neuroprotection in Glaucoma: A Narrative Review.J Clin Med. 2024 Apr 11;13(8):2214. doi: 10.3390/jcm13082214. J Clin Med. 2024. PMID: 38673487 Free PMC article. Review.
-
Herbal and Natural Treatments for the Management of the Glaucoma: An Update.Biomed Res Int. 2023 Nov 17;2023:3105251. doi: 10.1155/2023/3105251. eCollection 2023. Biomed Res Int. 2023. PMID: 38027044 Free PMC article. Review.
-
Neuroprotective Effect of a Nutritional Supplement Containing Spearmint Extract, Forskolin, Homotaurine and Group B Vitamins in a Mouse Model of Transient Ocular Hypertension.Biomedicines. 2023 May 18;11(5):1478. doi: 10.3390/biomedicines11051478. Biomedicines. 2023. PMID: 37239149 Free PMC article.
-
Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma.Nutrients. 2020 Oct 16;12(10):3158. doi: 10.3390/nu12103158. Nutrients. 2020. PMID: 33081127 Free PMC article. Review.
-
Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves".Wiley Interdiscip Rev Syst Biol Med. 2020 Sep;12(5):e1490. doi: 10.1002/wsbm.1490. Epub 2020 Apr 23. Wiley Interdiscip Rev Syst Biol Med. 2020. PMID: 32323924 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
