doi: 10.1099/0022-1317-32-2-301.
RNA-instructed DNA polymerase associated with C-type particles produced in vivo by murine myeloma cells
- PMID: 65443
- DOI: 10.1099/0022-1317-32-2-301
Item in Clipboard
RNA-instructed DNA polymerase associated with C-type particles produced in vivo by murine myeloma cells
J Gen Virol.
1976 Aug.
Abstract
C-type particles secreted in vivo by MOPC-315 myeloma cells were characterized. These particles localize at a density of 1-16 g/ml in sucrose and possess a 60 to 70S RNA and an RNA-instructed DNA polymerase. Endogenous enzyme activity requires manganese and is inhibited by ribonuclease or by the omission of any of the deoxynucleoside triphosphates. The enzyme utilizes the virus 60 to 70S RNA as a template to synthesize DNA molecules which specifically hybridize to the homologous RNA.
Similar articles
-
RNA-directed DNA polymerase--properties and functions in oncogenic RNA viruses and cells.Prog Nucleic Acid Res Mol Biol. 1974;14(0):187-334. Prog Nucleic Acid Res Mol Biol. 1974. PMID: 4135976 Review. No abstract available.
-
Characterization of an endogenous RNA-dependent DNA polymerase associated with murine intracisternal A particles.J Virol. 1974 Mar;13(3):712-20. doi: 10.1128/JVI.13.3.712-720.1974. J Virol. 1974. PMID: 4132671 Free PMC article.
-
Reverse transcriptase--a general discussion.J Enzyme Inhib. 1992;6(1):9-34. doi: 10.3109/14756369209041353. J Enzyme Inhib. 1992. PMID: 1285305 Review. No abstract available.
-
Intracisternal A particles from FLOPC-1 BALB/c myeloma: presence of high-molecular-weight RNA and RNA-dependent DNA polymerase.J Virol. 1976 May;18(2):745-56. doi: 10.1128/JVI.18.2.745-756.1976. J Virol. 1976. PMID: 58076 Free PMC article.
-
Characterization of DNA polymerase and RNA associated with A-type particles from murine myeloma cells.J Virol. 1975 Feb;15(2):407-15. doi: 10.1128/JVI.15.2.407-415.1975. J Virol. 1975. PMID: 46284 Free PMC article.
Cited by
-
Hamster endogenous retrovirus (HaER) isolated from SV-40 induced tumor cells.Arch Virol. 1983;78(3-4):233-44. doi: 10.1007/BF01311318. Arch Virol. 1983. PMID: 6197952
-
RNA-dependent DNA polymerase of an endogenous type C virus of mice: purification and partial characterization.J Virol. 1980 Jun;34(3):795-801. doi: 10.1128/JVI.34.3.795-801.1980. J Virol. 1980. PMID: 6155478 Free PMC article.
-
Characterization of the proteins of intracisternal type A and extracellular oncornavirus-like particles produced by MOPC-460 myeloma cells.J Virol. 1979 Oct;32(1):114-22. doi: 10.1128/JVI.32.1.114-122.1979. J Virol. 1979. PMID: 232164 Free PMC article.
-
Type C virus and immunoglobulin A production by murine myeloma MOPC-315: two independent activities.Infect Immun. 1979 Aug;25(2):569-73. doi: 10.1128/iai.25.2.569-573.1979. Infect Immun. 1979. PMID: 226480 Free PMC article.
-
Iododeoxyuridine activation of oncornavirus-like particles of hamster origin.Br J Cancer. 1977 Sep;36(3):397-9. doi: 10.1038/bjc.1977.208. Br J Cancer. 1977. PMID: 200255 Free PMC article. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
