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. 1983 Sep;53(3):744-9.

Modulation of murine lymphocyte and macrophage proliferation by parenteral zinc

M J Murray, F D Wilson, G L Fisher, K L Erickson

Modulation of murine lymphocyte and macrophage proliferation by parenteral zinc

M J Murray et al. Clin Exp Immunol. 1983 Sep.

Abstract

The effects of a single i.p. injection of zinc (0.7, 1.3, 4.0 or 12.0 mg/kg), 24 h prior to sacrifice, on lymphocyte blastogenesis as well as lymphocyte and macrophage progenitor cell proliferation were examined using cells from adult BALB/c mice. Splenic lymphocyte blastogenesis in response to T cell mitogens decreased for mice receiving the highest zinc dosage while responses to B cell mitogens were initially depressed, subsequently increased, and finally declined sharply as the LD50 was approached. Splenic B cell colony formation decreased linearly in relation to zinc dosage with a 50% suppression of colony formation observed at approximately 8.0 mg/kg. In contrast, bone marrow granulocyte-macrophage colonies were enhanced at higher dosages (greater than or equal to 2.5 mg/kg) of zinc. These results indicate that zinc exposure at dosages less than the LD50 can influence lymphocyte blastogenesis and clonal expansion of both B cell and macrophage progenitors.

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References

    1. J Nutr. 1978 May;108(5):881-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Jan;76(1):457-61 - PubMed
    1. Med Clin North Am. 1976 Jul;60(4):675-85 - PubMed
    1. Annu Rev Pharmacol Toxicol. 1979;19:393-426 - PubMed
    1. J Reticuloendothel Soc. 1979 Apr;25(4):345-50 - PubMed

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