Growth and development of human adipose tissue during early gestation
- PMID: 6851910
- DOI: 10.1016/0378-3782(83)90028-2
Growth and development of human adipose tissue during early gestation
Abstract
805 normal-for-age human embryos and fetuses were used to study early prenatal fat development. The investigation included observations on stages of fat morphogenesis at the light microscopic level and computerized image analyses of fat lobule size and number. The buccal fat pad was selected as a model system for the analyses. Fat tissue differentiates between the 14th and the 16th weeks: there are five morphogenic phases in adipose tissue formation, strongly associated with the formation of blood vessels. Fat lobules are the earliest structures to be identified before typical vacuolated fat cells appear. Concerning fat lobule size and number, we show that after the 23rd week the total number of fat lobules remains approximately constant, while from the 23rd to 29th week the growth of adipose tissue is determined mainly by an increase in size of the lobules. These results suggest that the 14th through the 23rd week is a sensitive period in fat lobule development, and that disturbances of normal adipogenesis during this period may play a role in the etiology of obesity in later life.
Similar articles
-
Adipose tissue growth patterns during human gestation: a histometric comparison of buccal and gluteal fat depots.Int J Obes. 1985;9(4):247-56. Int J Obes. 1985. PMID: 4066112
-
[Adipose tissue in the human cheek. Prenatal histological study].An Fac Odontol. 1978;(19):37-53. An Fac Odontol. 1978. PMID: 314244 Spanish. No abstract available.
-
The chronology of adipose tissue appearance and distribution in the human fetus.Early Hum Dev. 1984 Sep;10(1-2):1-11. doi: 10.1016/0378-3782(84)90106-3. Early Hum Dev. 1984. PMID: 6499712
-
Nutritional manipulations in the perinatal period program adipose tissue in offspring.Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1195-207. doi: 10.1152/ajpendo.00231.2013. Epub 2013 Sep 17. Am J Physiol Endocrinol Metab. 2013. PMID: 24045869 Review.
-
Adipocytes and adipose tissue.Best Pract Res Clin Endocrinol Metab. 2008 Feb;22(1):135-53. doi: 10.1016/j.beem.2007.10.002. Best Pract Res Clin Endocrinol Metab. 2008. PMID: 18279785 Review.
Cited by
-
Frequency of MRI Low Signal Intensity in the Buccal Fat of Fetuses and Speculation as to What It May Reflect.Children (Basel). 2024 Apr 12;11(4):463. doi: 10.3390/children11040463. Children (Basel). 2024. PMID: 38671680 Free PMC article.
-
Sex-Specific Perturbation of Systemic Lipidomic Profile in Newborn Lambs Impacted by Prenatal Testosterone Excess.Endocrinology. 2023 Dec 23;165(2):bqad187. doi: 10.1210/endocr/bqad187. Endocrinology. 2023. PMID: 38060679
-
Adipose Tissue Hyperplasia and Hypertrophy in Common and Syndromic Obesity-The Case of BBS Obesity.Nutrients. 2023 Aug 4;15(15):3445. doi: 10.3390/nu15153445. Nutrients. 2023. PMID: 37571382 Free PMC article. Review.
-
Association between maternal erythrocyte polyunsaturated fatty acid levels during pregnancy and offspring weight status: A birth cohort study.Front Nutr. 2022 Sep 29;9:978679. doi: 10.3389/fnut.2022.978679. eCollection 2022. Front Nutr. 2022. PMID: 36245520 Free PMC article.
-
Adipose Tissue Development Relies on Coordinated Extracellular Matrix Remodeling, Angiogenesis, and Adipogenesis.Biomedicines. 2022 Sep 8;10(9):2227. doi: 10.3390/biomedicines10092227. Biomedicines. 2022. PMID: 36140327 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
