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Comparative Study
. 1981 Jan;31(1):77-80.
doi: 10.1212/wnl.31.1.77.

Twin study of Parkinson disease

R C Duvoisin, R Eldridge, A Williams, J Nutt, D Calne
Comparative Study

Twin study of Parkinson disease

R C Duvoisin et al. Neurology. 1981 Jan.

Abstract

Zero concordance for Parkinson disease was found in the first 12 monozygotic twin pairs examined in an ongoing twin study. One co-twin (subject without Parkinson disease) had essential tremor, another had cerebral vascular disease, and a third was an alcoholic. Cigarette smoking appeared to be less frequent in the probands than in the co-twins (11.9 versus 16.1 pack-years). There was also evidence of premorbid personality differences between probands and co-twins dating back to late adolescence or early adult years. These preliminary findings suggest that genetic factors do not play a major role in the etiology of Parkinson disease and point to a prodromal onset of the disease as early as late adolescence or early adult life.

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