doi: 10.1126/science.7521539.
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
Affiliations
- PMID: 7521539
- DOI: 10.1126/science.7521539
Item in Clipboard
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
Science.
.
Abstract
As normal cells progress toward malignancy, they must switch to an angiogenic phenotype to attract the nourishing vasculature that they depend on for their growth. In cultured fibroblasts from Li-Fraumeni patients, this switch was found to coincide with loss of the wild-type allele of the p53 tumor suppressor gene and to be the result of reduced expression of thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis. Transfection assays revealed that p53 can stimulate the endogenous TSP-1 gene and positively regulate TSP-1 promoter sequences. These data indicate that, in fibroblasts, wild-type p53 inhibits angiogenesis through regulation of TSP-1 synthesis.
Similar articles
-
Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity.Oncogene. 1997 Mar 27;14(12):1495-502. doi: 10.1038/sj.onc.1200977. Oncogene. 1997. PMID: 9136993
-
Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression.J Natl Cancer Inst. 1997 Feb 5;89(3):219-27. doi: 10.1093/jnci/89.3.219. J Natl Cancer Inst. 1997. PMID: 9017002
-
Expression of thrombospondin-1 in cancer: a role in tumor progression.Proc Soc Exp Biol Med. 1996 Jul;212(3):199-207. doi: 10.3181/00379727-212-44008. Proc Soc Exp Biol Med. 1996. PMID: 8677265 Review.
-
The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression.Breast Cancer Res Treat. 1995;36(2):119-26. doi: 10.1007/BF00666034. Breast Cancer Res Treat. 1995. PMID: 8534861 Review.
-
The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.Cold Spring Harb Symp Quant Biol. 1994;59:483-9. doi: 10.1101/sqb.1994.059.01.053. Cold Spring Harb Symp Quant Biol. 1994. PMID: 7587102 No abstract available.
Cited by
-
Stromal cells in the tumor microenvironment: accomplices of tumor progression?Cell Death Dis. 2023 Sep 4;14(9):587. doi: 10.1038/s41419-023-06110-6. Cell Death Dis. 2023. PMID: 37666813 Free PMC article. Review.
-
Regression of Human Breast Carcinoma in Nude Mice after Adsflt Gene Therapy Is Mediated by Tumor Vascular Endothelial Cell Apoptosis.Cancers (Basel). 2022 Dec 14;14(24):6175. doi: 10.3390/cancers14246175. Cancers (Basel). 2022. PMID: 36551660 Free PMC article.
-
Molecular Mechanisms and Future Implications of VEGF/VEGFR in Cancer Therapy.Clin Cancer Res. 2023 Jan 4;29(1):30-39. doi: 10.1158/1078-0432.CCR-22-1366. Clin Cancer Res. 2023. PMID: 35969170 Free PMC article. Review.
-
Studying molecular signaling in major angiogenic diseases.Mol Cell Biochem. 2022 Oct;477(10):2433-2450. doi: 10.1007/s11010-022-04452-x. Epub 2022 May 18. Mol Cell Biochem. 2022. PMID: 35581517 Review.
-
The Prognostic Role and Significance of Dll4 and Toll-like Receptors in Cancer Development.Cancers (Basel). 2022 Mar 24;14(7):1649. doi: 10.3390/cancers14071649. Cancers (Basel). 2022. PMID: 35406423 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
etc
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
