Epstein-Barr virus isolates with the major HLA B35.01-restricted cytotoxic T lymphocyte epitope are prevalent in a highly B35.01-positive African population
- PMID: 7531142
- DOI: 10.1002/eji.1830250119
Epstein-Barr virus isolates with the major HLA B35.01-restricted cytotoxic T lymphocyte epitope are prevalent in a highly B35.01-positive African population
Abstract
An influence of cytotoxic T lymphocyte (CTL) response over Epstein-Barr virus (EBV) evolution was first suggested by the finding that virus isolates from highly HLA-A11-positive Oriental populations were specifically mutated in two immunodominant A11-restricted CTL epitopes. Here we turn to a second HLA allele, B35.01 and show that B35.01-restricted CTL responses in Caucasian donors reproducibly map to a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 EBV nuclear antigen 3A protein (B95.8 strain). In this case, however, most EBV isolates from a highly B35.01-positive population (in The Gambia) either retained the CTL epitope sequence or carried a mutation (P-->S at position 2) which conserved antigenicity; changes leading to reduced antigenicity (Y-->N at position 1) were found in only a minority of cases. Furthermore, CTL recognizing the YPLHEQHGM epitope could be reactivated from the blood of some B35.01-positive Gambian donors by in vitro stimulation with the synthetic peptide, indicating that epitope-specific immunity does exist in this population. Possible differences between the A11-based and B35.01-based studies are discussed.
Similar articles
-
Cross-reactive memory T cells for Epstein-Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex-bound peptide by T cells and its role in alloreactivity.Eur J Immunol. 1997 Jul;27(7):1726-36. doi: 10.1002/eji.1830270720. Eur J Immunol. 1997. PMID: 9247584
-
T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues.J Exp Med. 1994 Apr 1;179(4):1297-305. doi: 10.1084/jem.179.4.1297. J Exp Med. 1994. PMID: 7511684 Free PMC article.
-
Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities.J Immunol. 1995 Feb 1;154(3):1287-95. J Immunol. 1995. PMID: 7529799
-
Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection.Annu Rev Immunol. 1997;15:405-31. doi: 10.1146/annurev.immunol.15.1.405. Annu Rev Immunol. 1997. PMID: 9143694 Review.
-
Transformation-associated Epstein-Barr virus antigens as targets for immune attack.Ann N Y Acad Sci. 1993 Aug 12;690:86-100. doi: 10.1111/j.1749-6632.1993.tb43999.x. Ann N Y Acad Sci. 1993. PMID: 7690218 Review. No abstract available.
Cited by
-
Immunoinformatic Analysis Reveals Antigenic Heterogeneity of Epstein-Barr Virus Is Immune-Driven.Front Immunol. 2021 Dec 16;12:796379. doi: 10.3389/fimmu.2021.796379. eCollection 2021. Front Immunol. 2021. PMID: 34975903 Free PMC article.
-
Specific mutation of a gammaherpesvirus-expressed antigen in response to CD8 T cell selection in vivo.J Virol. 2012 Mar;86(5):2887-93. doi: 10.1128/JVI.06101-11. Epub 2011 Dec 14. J Virol. 2012. PMID: 22171269 Free PMC article.
-
Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.Immunogenetics. 2009 Dec;61(11-12):703-16. doi: 10.1007/s00251-009-0399-2. Immunogenetics. 2009. PMID: 19838694 Free PMC article.
-
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.PLoS One. 2008 Aug 13;3(8):e2921. doi: 10.1371/journal.pone.0002921. PLoS One. 2008. PMID: 18698342 Free PMC article.
-
Latent gene sequencing reveals familial relationships among Chinese Epstein-Barr virus strains and evidence for positive selection of A11 epitope changes.J Virol. 2003 Nov;77(21):11517-30. doi: 10.1128/jvi.77.21.11517-11530.2003. J Virol. 2003. PMID: 14557637 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials