Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Oct;96(4):1815-22.
doi: 10.1172/JCI118227.

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

P C Brooks  1 , S Strömblad, R Klemke, D Visscher, F H Sarkar, D A Cheresh
Affiliations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

P C Brooks et al. J Clin Invest. 1995 Oct.

Abstract

Angiogenesis plays a fundamental role in human breast tumor progression. In fact, recent findings indicate that vascular density is a prognostic indicator of breast cancer disease status. Evidence is presented that the integrin alpha v beta 3 is not only a marker of human breast tumor-associated blood vessels, but that it plays a significant role in human angiogenesis and breast tumor growth. To assess the role of alpha v beta 3-dependent angiogenesis in the progression of human breast cancer, we examined a SCID mouse/human chimeric model with transplanted full thickness human skin containing alpha v beta 3-negative human breast tumor cells. This tumor induced a human angiogenic response as measured by vascular cell immunoreactivity with monoclonal antibodies LM609 and P2B1 directed to human alpha v beta 3 and CD31, respectively. Intravenous administration of LM609 either prevented tumor growth or markedly reduced tumor cell proliferation within the microenvironment of the human skin. These LM609-treated tumors not only contained significantly fewer human blood vessels but also appeared considerably less invasive than tumors in control animals. These findings demonstrate that alpha v beta 3 antagonists may provide an effective antiangiogenic approach for the treatment of human breast cancer.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Science. 1994 Apr 22;264(5158):569-71 - PubMed
    1. Biochim Biophys Acta. 1990 Jun 1;1032(1):89-118 - PubMed
    1. Semin Cancer Biol. 1992 Apr;3(2):49-56 - PubMed
    1. Lancet. 1992 Nov 7;340(8828):1120-4 - PubMed
    1. Am J Pathol. 1993 Aug;143(2):528-37 - PubMed

Publication types

Substances

-