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. 1995 Oct 20;83(2):247-56.
doi: 10.1016/0092-8674(95)90166-3.

Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions

A W Kerrebrock  1 , D P Moore, J S Wu, T L Orr-Weaver
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Free article

Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions

A W Kerrebrock et al. Cell. .
Free article

Abstract

Mutations in the Drosophila mei-S332 gene cause premature separation of the sister chromatids in late anaphase of meiosis I. Therefore, the mei-S332 protein was postulated to hold the centromere regions of sister chromatids together until anaphase II. The mei-S332 gene encodes a novel 44 kDa protein. Mutations in mei-S332 that differentially affect function in males or females map to distinct domains of the protein. A fusion of mei-S332 to the green fluorescent protein (GFP) is fully functional and localizes specifically to the centromere region of meiotic chromosomes. When sister chromatids separate at anaphase II, mei-S332-GFP disappears from the chromosomes, suggesting that the destruction or release of this protein is required for sister-chromatid separation.

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Comment in

  • The bond between sisters.
    Sekelsky JJ, Hawley RS. Sekelsky JJ, et al. Cell. 1995 Oct 20;83(2):157-60. doi: 10.1016/0092-8674(95)90156-6. Cell. 1995. PMID: 7585932 Review. No abstract available.

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