A new Escherichia coli cell division gene, ftsK
- PMID: 7592387
- PMCID: PMC177462
- DOI: 10.1128/jb.177.21.6211-6222.1995
A new Escherichia coli cell division gene, ftsK
Abstract
A mutation in a newly discovered Escherichia coli cell division gene, ftsK, causes a temperature-sensitive late-stage block in division but does not affect chromosome replication or segregation. This defect is specifically suppressed by deletion of dacA, coding for the peptidoglycan DD-carboxypeptidase, PBP 5. FtsK is a large polypeptide (147 kDa) consisting of an N-terminal domain with several predicted membrane-spanning regions, a proline-glutamine-rich domain, and a C-terminal domain with a nucleotide-binding consensus sequence. FtsK has extensive sequence identity with a family of proteins from a wide variety of prokaryotes and plasmids. The plasmid proteins are required for intercellular DNA transfer, and one of the bacterial proteins (the SpoIIIE protein of Bacillus subtilis) has also been implicated in intracellular chromosomal DNA transfer.
Similar articles
-
Cloning and sequencing of the cell division gene pbpB, which encodes penicillin-binding protein 2B in Bacillus subtilis.J Bacteriol. 1993 Dec;175(23):7604-16. doi: 10.1128/jb.175.23.7604-7616.1993. J Bacteriol. 1993. PMID: 8244929 Free PMC article.
-
Localization of cell division protein FtsK to the Escherichia coli septum and identification of a potential N-terminal targeting domain.J Bacteriol. 1998 Mar;180(5):1296-304. doi: 10.1128/JB.180.5.1296-1304.1998. J Bacteriol. 1998. PMID: 9495771 Free PMC article.
-
Differential effect of mutational impairment of penicillin-binding proteins 1A and 1B on Escherichia coli strains harboring thermosensitive mutations in the cell division genes ftsA, ftsQ, ftsZ, and pbpB.J Bacteriol. 1990 Oct;172(10):5863-70. doi: 10.1128/jb.172.10.5863-5870.1990. J Bacteriol. 1990. PMID: 2211517 Free PMC article.
-
FtsK and SpoIIIE, coordinators of chromosome segregation and envelope remodeling in bacteria.Trends Microbiol. 2022 May;30(5):480-494. doi: 10.1016/j.tim.2021.10.002. Epub 2021 Oct 30. Trends Microbiol. 2022. PMID: 34728126 Review.
-
The regulation of bacterial cell division: a time and place for it.Curr Opin Microbiol. 1998 Apr;1(2):210-5. doi: 10.1016/s1369-5274(98)80013-1. Curr Opin Microbiol. 1998. PMID: 10066481 Review.
Cited by
-
TipN's involvement with centromere segregation in Caulobacter crescentus.bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572679. doi: 10.1101/2023.12.20.572679. bioRxiv. 2023. Update in: Mol Biol Cell. 2024 May 1;35(5):ar68. doi: 10.1091/mbc.E23-12-0503. PMID: 38187783 Free PMC article. Updated. Preprint.
-
The mobilome of Lactobacillus crispatus M247 includes two novel genetic elements: Tn7088 coding for a putative bacteriocin and the siphovirus prophage ΦM247.Microb Genom. 2023 Dec;9(12):001150. doi: 10.1099/mgen.0.001150. Microb Genom. 2023. PMID: 38085804 Free PMC article.
-
The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp.mBio. 2023 Oct 26;14(6):e0242523. doi: 10.1128/mbio.02425-23. Online ahead of print. mBio. 2023. PMID: 37882534 Free PMC article.
-
FtsK, a DNA Motor Protein, Coordinates the Genome Segregation and Early Cell Division Processes in Deinococcus radiodurans.mBio. 2022 Dec 20;13(6):e0174222. doi: 10.1128/mbio.01742-22. Epub 2022 Oct 27. mBio. 2022. PMID: 36300930 Free PMC article.
-
Localization, Assembly, and Activation of the Escherichia coli Cell Division Machinery.EcoSal Plus. 2021 Dec 15;9(2):eESP00222021. doi: 10.1128/ecosalplus.ESP-0022-2021. Epub 2021 Dec 13. EcoSal Plus. 2021. PMID: 34910577 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
