L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells
- PMID: 7605635
- DOI: 10.1016/0896-6273(95)90273-2
L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells
Abstract
Granule cells in the guinea pig dentate gyrus release kappa opioid neuropeptides, dynorphins, from dendrites as well as from axon terminals. We have found that both L- and N-type calcium channel antagonists inhibited dendritic dynorphin release. In contrast, N-type but not L-type calcium channel antagonists inhibited axonal dynorphin release. Neither L- nor N-type channel antagonists directly altered the effects of kappa opioid receptor activation. By inhibiting dynorphin release, L-type channel antagonists also facilitated the induction of long-term potentiation of the perforant path-granule cell synapse. These studies establish that a single cell type can release a transmitter from two different cellular domains and provide new distinction between axonal and dendritic transmitter release mechanisms.
Similar articles
-
Opioid modulation of recurrent excitation in the hippocampal dentate gyrus.J Neurosci. 2000 Jun 15;20(12):4379-88. doi: 10.1523/JNEUROSCI.20-12-04379.2000. J Neurosci. 2000. PMID: 10844006 Free PMC article.
-
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.J Neurophysiol. 1998 Feb;79(2):753-62. doi: 10.1152/jn.1998.79.2.753. J Neurophysiol. 1998. PMID: 9463438
-
Limited regulation of somatodendritic dopamine release by voltage-sensitive Ca channels contrasted with strong regulation of axonal dopamine release.J Neurochem. 2006 Feb;96(3):645-55. doi: 10.1111/j.1471-4159.2005.03519.x. Epub 2006 Jan 9. J Neurochem. 2006. PMID: 16405515
-
Endogenous opioid regulation of hippocampal function.Int Rev Neurobiol. 1996;39:145-96. doi: 10.1016/s0074-7742(08)60666-2. Int Rev Neurobiol. 1996. PMID: 8894847 Review.
-
The role of Ca2+ in transmitter release and long-term potentiation at hippocampal mossy fiber synapses.Adv Second Messenger Phosphoprotein Res. 1994;29:497-505. doi: 10.1016/s1040-7952(06)80031-5. Adv Second Messenger Phosphoprotein Res. 1994. PMID: 7848728 Review. No abstract available.
Cited by
-
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.Nat Biotechnol. 2023 Jul;41(7):944-957. doi: 10.1038/s41587-022-01561-2. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593404 Free PMC article.
-
The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder.Neuropharmacology. 2023 Mar 1;225:109376. doi: 10.1016/j.neuropharm.2022.109376. Epub 2022 Dec 11. Neuropharmacology. 2023. PMID: 36516892 Free PMC article. Review.
-
Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases.Biomedicines. 2022 Feb 1;10(2):343. doi: 10.3390/biomedicines10020343. Biomedicines. 2022. PMID: 35203552 Free PMC article. Review.
-
The Thermodynamically Expensive Contribution of Three Calcium Sources to Somatic Release of Serotonin.Int J Mol Sci. 2022 Jan 28;23(3):1495. doi: 10.3390/ijms23031495. Int J Mol Sci. 2022. PMID: 35163419 Free PMC article. Review.
-
Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin.Neuron. 2021 Nov 17;109(22):3619-3632.e5. doi: 10.1016/j.neuron.2021.08.015. Epub 2021 Sep 17. Neuron. 2021. PMID: 34536353 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
