The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus
- PMID: 7844558
- DOI: 10.1099/0022-1317-76-2-393
The asialoglycoprotein receptor is a potential liver-specific receptor for Marburg virus
Abstract
The liver is one of the main target organs of Marburg virus (MBG), a filovirus causing severe haemorrhagic fever with a high fatality rate in humans and non-human primates. MBG grown in certain cells does not contain neuraminic acid, but has terminal galactose on its surface glycoprotein. This observation indicated that the asialoglycoprotein receptor (ASGP-R) of hepatocytes may serve as a receptor for MBG in the liver. Binding studies revealed that the attachment of MBG to ASGP-R-expressing HepG2 cells, but not to ASGP-R-negative E6 Vero cells, has the characteristics of ligand binding to the ASGP-R: binding is dependent on calcium and is inhibited by excess asialofetuin and by anti-ASGP-R antiserum. Asialofetuin and the specific antiserum also inhibited MBG infection of HepG2 cells. In addition, it was shown that expression of ASGP-R cDNA in NIH 3T3 cells enhanced the susceptibility of these cells to MBG infection 4.5-fold. Interaction of MBG with the hepatic ASGP-R could thus explain the marked hepatotropism of the virus.
Similar articles
-
Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor.Bioconjug Chem. 2017 Feb 15;28(2):283-295. doi: 10.1021/acs.bioconjchem.6b00651. Epub 2016 Dec 27. Bioconjug Chem. 2017. PMID: 27966887 Review.
-
Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses.Cell. 2001 Jul 13;106(1):117-26. doi: 10.1016/s0092-8674(01)00418-4. Cell. 2001. PMID: 11461707
-
Circulating cellular fibronectin may be a natural ligand for the hepatic asialoglycoprotein receptor: possible pathway for fibronectin deposition and turnover in the rat liver.Hepatology. 1998 Aug;28(2):475-85. doi: 10.1002/hep.510280227. Hepatology. 1998. PMID: 9696014
-
The asialoglycoprotein receptor mediates hepatic binding and uptake of natural hepatitis B virus particles derived from viraemic carriers.J Gen Virol. 1994 Nov;75 ( Pt 11):3021-9. doi: 10.1099/0022-1317-75-11-3021. J Gen Virol. 1994. PMID: 7964611
-
Trafficking of asialoglycoproteins and the asialoglycoprotein receptor.Targeted Diagn Ther. 1991;4:3-39. Targeted Diagn Ther. 1991. PMID: 1797161 Review.
Cited by
-
Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats.Viruses. 2023 Jan 26;15(2):350. doi: 10.3390/v15020350. Viruses. 2023. PMID: 36851566 Free PMC article.
-
Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines.Pathogens. 2022 Nov 23;11(12):1400. doi: 10.3390/pathogens11121400. Pathogens. 2022. PMID: 36558734 Free PMC article. Review.
-
Combination treatment of mannose and GalNAc conjugated small interfering RNA protects against lethal Marburg virus infection.Mol Ther. 2023 Jan 4;31(1):269-281. doi: 10.1016/j.ymthe.2022.09.009. Epub 2022 Sep 15. Mol Ther. 2023. PMID: 36114672 Free PMC article.
-
Pathogenicity and virulence of Marburg virus.Virulence. 2022 Dec;13(1):609-633. doi: 10.1080/21505594.2022.2054760. Virulence. 2022. PMID: 35363588 Free PMC article. Review.
-
A Naturally Occurring Polymorphism in the Base of Sudan Virus Glycoprotein Decreases Glycoprotein Stability in a Species-Dependent Manner.J Virol. 2021 Aug 25;95(18):e0107321. doi: 10.1128/JVI.01073-21. Epub 2021 Aug 25. J Virol. 2021. PMID: 34232742 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
