Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan
- PMID: 7882325
Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan
Abstract
In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with blackfoot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.
Similar articles
-
Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers.Cancer Res. 1985 Nov;45(11 Pt 2):5895-9. Cancer Res. 1985. PMID: 4053060
-
Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan.Environ Res. 2010 Jul;110(5):455-62. doi: 10.1016/j.envres.2009.08.010. Epub 2009 Sep 6. Environ Res. 2010. PMID: 19735913
-
Risk assessment of arsenic-induced internal cancer at long-term low dose exposure.J Hazard Mater. 2009 Jun 15;165(1-3):652-63. doi: 10.1016/j.jhazmat.2008.10.095. Epub 2008 Nov 5. J Hazard Mater. 2009. PMID: 19062162
-
Blackfoot disease and arsenic: a never-ending story.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2005;23(1):55-74. doi: 10.1081/GNC-200051860. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2005. PMID: 16291522 Review.
-
Does arsenic exposure increase the risk for liver cancer?J Toxicol Environ Health A. 2004 Oct 8;67(19):1491-500. doi: 10.1080/15287390490486806. J Toxicol Environ Health A. 2004. PMID: 15371225 Review.
Cited by
-
Benchmark dose modeling for epidemiological dose-response assessment using prospective cohort studies.Risk Anal. 2024 Apr;44(4):743-756. doi: 10.1111/risa.14196. Epub 2023 Jul 27. Risk Anal. 2024. PMID: 37496455
-
Distribution and Speciation of Heavy Metal(loid)s in Soils under Multiple Preservative-Treated Wooden Trestles.Toxics. 2023 Mar 7;11(3):249. doi: 10.3390/toxics11030249. Toxics. 2023. PMID: 36977014 Free PMC article.
-
Associations and Interactions between Heavy Metals with White Blood Cell and Eosinophil Count.Int J Med Sci. 2022 Jan 9;19(2):331-337. doi: 10.7150/ijms.68945. eCollection 2022. Int J Med Sci. 2022. PMID: 35165518 Free PMC article.
-
Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor.Oxid Med Cell Longev. 2022 Jan 7;2022:3459855. doi: 10.1155/2022/3459855. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35039759 Free PMC article.
-
The association of arsenic exposure and arsenic metabolism with all-cause, cardiovascular and cancer mortality in the Strong Heart Study.Environ Int. 2022 Jan 15;159:107029. doi: 10.1016/j.envint.2021.107029. Epub 2021 Dec 7. Environ Int. 2022. PMID: 34890900 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical