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. 1994 Jun 24;264(5167):1918-21.
doi: 10.1126/science.8009221.

Functional role of type I and type II interferons in antiviral defense

U Müller  1 , U Steinhoff, L F Reis, S Hemmi, J Pavlovic, R M Zinkernagel, M Aguet
Affiliations

Functional role of type I and type II interferons in antiviral defense

U Müller et al. Science. .

Abstract

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

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