Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG, and absence of cross-immunity on challege in vivo
- PMID: 806649
- PMCID: PMC2189902
- DOI: 10.1084/jem.142.2.299
Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG, and absence of cross-immunity on challege in vivo
Abstract
Peritoneal macrophages from T. cruzi-immune mice were resistant to infection in vitro with culture forms of the parasite. Macrophage resistance appeared in infected mice about 21 days postinfection when parasitemia was still rising. Resistance in vitro was nonspecific since macrophages from BCG-immune mice were resistant to T. cruzi, and since macrophages from T. cruzi-immune mice were resistant to infection in vitro with Listeria were not resistant to challenge with T. cruzi even when the parasites were opsonized.
Similar articles
-
Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi.Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):107-24. doi: 10.1016/j.cytogfr.2007.01.010. Epub 2007 Mar 6. Cytokine Growth Factor Rev. 2007. PMID: 17339126 Review.
-
Trypanosoma cruzi: the fate of bloodstream trypomastigote, amastigote, metacyclic trypomastigote and epimastigote forms in the peritoneal macrophages of immune and non-immune mice in vivo.Acta Trop. 1982 Jun;39(2):111-22. Acta Trop. 1982. PMID: 6126093
-
The biology of Trypanosoma cruzi-macrophage interaction.Mem Inst Oswaldo Cruz. 1989 Oct-Dec;84(4):441-62. doi: 10.1590/s0074-02761989000400001. Mem Inst Oswaldo Cruz. 1989. PMID: 2487443 Review. No abstract available.
-
Resistance of Trypanosoma cruzi to killing by macrophages.Nature. 1975 Oct 2;257(5525):394-6. doi: 10.1038/257394a0. Nature. 1975. PMID: 809716 No abstract available.
-
Trypanosoma cruzi: modification of macrophage function during infection.J Exp Med. 1977 Jul 1;146(1):157-71. doi: 10.1084/jem.146.1.157. J Exp Med. 1977. PMID: 327012 Free PMC article.
Cited by
-
Mycobacterium bovis BCG as immunostimulating agent prevents the severe form of chronic experimental Chagas disease.Front Immunol. 2024 Mar 21;15:1380049. doi: 10.3389/fimmu.2024.1380049. eCollection 2024. Front Immunol. 2024. PMID: 38576607 Free PMC article.
-
Optimization of the Timing of Induction for the Assessment of Nitric Oxide Production in Leishmania major Infected Macrophage Cells.Iran J Parasitol. 2016 Jul-Sep;11(3):325-331. Iran J Parasitol. 2016. PMID: 28127337 Free PMC article.
-
High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi.Parasitol Int. 2010 Dec;59(4):565-70. doi: 10.1016/j.parint.2010.07.007. Epub 2010 Aug 3. Parasitol Int. 2010. PMID: 20688189 Free PMC article.
-
Enhanced antigen-presenting activity and tumour necrosis factor-alpha-independent activation of dendritic cells following treatment with Mycobacterium bovis bacillus Calmette-Guérin.Immunology. 1999 Aug;97(4):626-33. doi: 10.1046/j.1365-2567.1999.00818.x. Immunology. 1999. PMID: 10457216 Free PMC article.
-
Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice.Infect Immun. 1998 Jun;66(6):2960-8. doi: 10.1128/IAI.66.6.2960-2968.1998. Infect Immun. 1998. PMID: 9596773 Free PMC article.