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. 1994 Sep 10;309(6955):636-8.
doi: 10.1136/bmj.309.6955.636.

Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

J Kuusisto  1 , K Koivisto, K Kervinen, L Mykkänen, E L Helkala, M Vanhanen, T Hänninen, K Pyörälä, Y A Kesäniemi, P Riekkinen, et al.
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Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

J Kuusisto et al. BMJ. .

Abstract

Objective: To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.

Design: Cross sectional population based study.

Subjects: 980 people aged 69 to 78 (349 men, 631 women).

Setting: Population of Kuopio, eastern Finland.

Main outcome measures: Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.

Results: 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.

Conclusions: Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.

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References

    1. Brain. 1966 Mar;89(1):53-82 - PubMed
    1. Lancet. 1974 Jul 27;2(7874):207-10 - PubMed
    1. Neurology. 1974 Nov;24(11):1019-25 - PubMed
    1. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
    1. Neurology. 1984 Jul;34(7):939-44 - PubMed

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