doi: 10.1038/364771a0.
Association of folding intermediates of glycoproteins with calnexin during protein maturation
Affiliations
- PMID: 8102790
- DOI: 10.1038/364771a0
Item in Clipboard
Association of folding intermediates of glycoproteins with calnexin during protein maturation
Nature.
.
Abstract
Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoproteins from calnexin occurs at different rates and is related to the time taken for their folding, which may then initiate their differential transport rates from the endoplasmic reticulum.
Similar articles
-
Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum.J Cell Sci. 2006 Feb 15;119(Pt 4):615-23. doi: 10.1242/jcs.02856. J Cell Sci. 2006. PMID: 16467570 Review.
-
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.Science. 2003 Feb 28;299(5611):1397-400. doi: 10.1126/science.1079474. Science. 2003. PMID: 12610306
-
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin.Science. 2003 Feb 28;299(5611):1394-7. doi: 10.1126/science.1079181. Science. 2003. PMID: 12610305
-
Lectins as chaperones in glycoprotein folding.Curr Opin Struct Biol. 1998 Oct;8(5):587-92. doi: 10.1016/s0959-440x(98)80148-6. Curr Opin Struct Biol. 1998. PMID: 9818262 Review.
-
Calnexin associates with the precursors of glycoproteins B, C, and D of herpes simplex virus type 1.Virology. 1996 Nov 1;225(1):216-22. doi: 10.1006/viro.1996.0590. Virology. 1996. PMID: 8918549
Cited by
-
Activation of Ca2+ transport in cardiac microsomes enriches functional sets of ER and SR proteins.Mol Cell Biochem. 2024 Jan;479(1):85-98. doi: 10.1007/s11010-023-04708-0. Epub 2023 Apr 10. Mol Cell Biochem. 2024. PMID: 37036634 Free PMC article.
-
Activation of Ca transport in cardiac microsomes enriches functional sets of ER and SR proteins.Res Sq [Preprint]. 2023 Feb 8:rs.3.rs-2557992. doi: 10.21203/rs.3.rs-2557992/v1. Res Sq. 2023. Update in: Mol Cell Biochem. 2024 Jan;479(1):85-98. doi: 10.1007/s11010-023-04708-0. PMID: 36798315 Free PMC article. Updated. Preprint.
-
Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking.Neuron. 2022 Feb 2;110(3):436-451.e11. doi: 10.1016/j.neuron.2021.10.032. Epub 2021 Nov 17. Neuron. 2022. PMID: 34793693 Free PMC article.
-
Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise.Proteomics. 2021 Dec;21(23-24):e2000143. doi: 10.1002/pmic.202000143. Epub 2021 Aug 9. Proteomics. 2021. PMID: 34310018 Free PMC article. Review.
-
Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site.J Biol Chem. 2020 Dec 11;295(50):17227-17240. doi: 10.1074/jbc.RA120.014919. Epub 2020 Oct 13. J Biol Chem. 2020. PMID: 33051205 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
