doi: 10.1126/science.8266081.
Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc
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- PMID: 8266081
- DOI: 10.1126/science.8266081
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Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc
Science.
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Abstract
Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.
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