EGF receptor in neoplasia and metastasis
- PMID: 8281612
- DOI: 10.1007/BF00665957
EGF receptor in neoplasia and metastasis
Abstract
EGFR is a member of the tyrosine kinase family of cell surface receptors with a wide range of expression throughout development and in a variety of different cell types. The receptor can transmit signals to cells: i) upon interaction with ligands such as EGF, TGF alpha, amphiregulin or heparin binding EGF, ii) upon truncation or mutation of extracellular and/or intracellular domains, iii) upon amplification of a basal receptor activity (in the absence of ligand) through cooperation with other cellular signaling pathways or nuclear events (e.g. expression of v-erbA). The activated EGFR can exert pleiotropic functions on cells, depending on their tissue origin and state of differentiation. Under certain conditions it can also contribute to neoplasia and development of metastases. Such conditions can exist upon aberrant receptor/ligand expression and activation (e.g. in the wrong cell; at the wrong time; in the wrong amounts). Aberrant signalling can also occur through constitutive EGFR activation. Oncogenic potential of EGFR has been demonstrated in a wide range of experimental animals. EGFR is also implicated in human cancer, where it may contribute both to the initiation (glioblastoma) and progression (epithelial tumors) of the disease. EGFR may influence key steps in the processes of tumor invasion and dissemination. Involvement of EGFR in tumor spread may indicate a potential use of this receptor as a target for antimetastatic therapy.
Similar articles
-
EGF receptor.Int J Biochem Cell Biol. 1999 Jun;31(6):637-43. doi: 10.1016/s1357-2725(99)00015-1. Int J Biochem Cell Biol. 1999. PMID: 10404636 Review.
-
Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options.Recent Results Cancer Res. 2003;162:115-32. doi: 10.1007/978-3-642-59349-9_10. Recent Results Cancer Res. 2003. PMID: 12790326 Review.
-
Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research.Breast Cancer Res Treat. 1995 Jul;35(1):115-32. doi: 10.1007/BF00694752. Breast Cancer Res Treat. 1995. PMID: 7612898 Review.
-
The ErbB/HER family of protein-tyrosine kinases and cancer.Pharmacol Res. 2014 Jan;79:34-74. doi: 10.1016/j.phrs.2013.11.002. Epub 2013 Nov 20. Pharmacol Res. 2014. PMID: 24269963 Review.
-
EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines.J Clin Neurosci. 2002 May;9(3):282-8. doi: 10.1054/jocn.2001.1063. J Clin Neurosci. 2002. PMID: 12093135
Cited by
-
Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk model.Front Oncol. 2023 Jun 15;13:1109037. doi: 10.3389/fonc.2023.1109037. eCollection 2023. Front Oncol. 2023. PMID: 37397378 Free PMC article.
-
Ez-Metastasizing: The Crucial Roles of Ezrin in Metastasis.Cells. 2023 Jun 14;12(12):1620. doi: 10.3390/cells12121620. Cells. 2023. PMID: 37371090 Free PMC article. Review.
-
Ras Signaling in Breast Cancer.Adv Exp Med Biol. 2021;1187:81-101. doi: 10.1007/978-981-32-9620-6_4. Adv Exp Med Biol. 2021. PMID: 33983574
-
Intratumoral Cancer Chemotherapy with a Carrier-Based Immunogenic Cell-Death Eliciting Platinum (IV) Agent.Mol Pharm. 2020 Nov 2;17(11):4334-4345. doi: 10.1021/acs.molpharmaceut.0c00781. Epub 2020 Oct 8. Mol Pharm. 2020. PMID: 32975949 Free PMC article.
-
c-Src and EGFR Inhibition in Molecular Cancer Therapy: What Else Can We Improve?Cancers (Basel). 2020 Jun 7;12(6):1489. doi: 10.3390/cancers12061489. Cancers (Basel). 2020. PMID: 32517369 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials
Miscellaneous