Pathogenesis of testicular germ cell tumours
- PMID: 8386649
- DOI: 10.1159/000474563
Pathogenesis of testicular germ cell tumours
Abstract
Testicular germ cell tumours are subdivided clinically into two major groups: seminomas and non-seminomatous germ cell tumours (NSGCT). The relationship of seminomas to NSGCT remains controversial. The pathogenesis of NSGCT has been studied experimentally in mice, but there are no adequate experimental models of seminomas in laboratory rodents. Experiments with tumour cell lines derived from animal tumours have generated useful data for the better understanding of the biology of stem cells, such as embryonal carcinoma and yolk sac tumour. The final answer to questions pertaining to the histogenesis and classification of human germ cell tumours will however be obtained only after appropriate tumour cell lines of human origin are cloned.
Similar articles
-
Testicular germ cell tumours. Current problems of histogenesis and classification.Int Urol Nephrol. 1985;17(1):85-95. doi: 10.1007/BF02089407. Int Urol Nephrol. 1985. PMID: 2581914 Review.
-
Cultured stem-cells from human testicular teratomas: the nature of human embryonal carcinoma, and its comparison with two types of yolk-sac carcinoma.Int J Cancer. 1987 Sep 15;40(3):334-43. doi: 10.1002/ijc.2910400309. Int J Cancer. 1987. PMID: 2442105
-
Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases.Acta Radiol Oncol. 1984;23(4):239-47. doi: 10.3109/02841868409136019. Acta Radiol Oncol. 1984. PMID: 6093440
-
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.Mod Pathol. 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. Mod Pathol. 2005. PMID: 15761467 Review.
-
[Histogenesis of human embryonal cancer of the testis].Arkh Patol. 1986;48(2):29-35. Arkh Patol. 1986. PMID: 3010912 Russian.
Cited by
-
Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.J Biol Chem. 2012 Nov 16;287(47):39698-709. doi: 10.1074/jbc.M112.384057. Epub 2012 Sep 25. J Biol Chem. 2012. PMID: 23012353 Free PMC article.
-
H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cells.Genome Res. 2012 Jun;22(6):1026-35. doi: 10.1101/gr.120634.111. Epub 2012 Mar 15. Genome Res. 2012. PMID: 22421545 Free PMC article.
-
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5. doi: 10.1073/pnas.2235735100. Epub 2003 Oct 31. Proc Natl Acad Sci U S A. 2003. PMID: 14595015 Free PMC article.
-
From teratocarcinomas to embryonic stem cells.Philos Trans R Soc Lond B Biol Sci. 2002 Apr 29;357(1420):405-17. doi: 10.1098/rstb.2002.1058. Philos Trans R Soc Lond B Biol Sci. 2002. PMID: 12028783 Free PMC article. Review.
-
Ki-A10, a germ cell nuclear antigen retained in a subset of germ cell-derived tumors.Am J Pathol. 1999 Mar;154(3):795-803. doi: 10.1016/S0002-9440(10)65326-6. Am J Pathol. 1999. PMID: 10079257 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Medical