Clinical Trial
How long should the elderly take antidepressants? A double-blind placebo-controlled study of continuation/prophylaxis therapy with dothiepin. Old Age Depression Interest Group
- PMID: 8435687
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Clinical Trial
How long should the elderly take antidepressants? A double-blind placebo-controlled study of continuation/prophylaxis therapy with dothiepin. Old Age Depression Interest Group
Br J Psychiatry.
1993 Feb.
Abstract
Of 219 elderly patients with a major depressive disorder (meeting RDC), 69 recovered sufficiently and consented to enter a two-year double-blind placebo-controlled trial of dothiepin. Survival analysis revealed that dothiepin reduced the relative risk of relapse by two and a half times. Past but not current serious physical illness was also associated with a favourable outcome, whereas a prolonged index depressive illness trebled the relative risk of relapse. In the light of previous research on prognosis it is suggested that elderly persons who recover from a major depressive illness should continue with antidepressant medication for at least two years, if not indefinitely.
Comment in
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Failure to demonstrate prophylactic efficacy of dothiepin.Br J Psychiatry. 1993 Aug;163:257-8. doi: 10.1192/bjp.163.2.257. Br J Psychiatry. 1993. PMID: 7980821 No abstract available.
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Long-term antidepressant treatment in the elderly.Br J Psychiatry. 1993 Jul;163:126. doi: 10.1192/bjp.163.1.126b. Br J Psychiatry. 1993. PMID: 8257502 No abstract available.
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