Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
- PMID: 8513503
- DOI: 10.1016/0092-8674(93)90648-a
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
Abstract
The transcription of genes encoding soluble proteins that reside in the endoplasmic reticulum (ER) is induced when unfolded proteins accumulate in the ER. Thus, an intracellular signal transduction pathway must exist that mediates communication between the ER lumen and the nucleus. We have identified a gene in S. cerevisiae, IRE1, that is required for this pathway: ire1- mutants cannot activate transcription of KAR2 and PDI1, which encode the ER resident proteins BiP and protein disulfide isomerase. Moreover, IRE1 is essential for cell viability under stress conditions that cause unfolded proteins to accumulate in the ER. IRE1 encodes a transmembrane serine/threonine kinase that we propose transmits the unfolded protein signal across the ER or inner nuclear membrane. IRE1 is also required for inositol prototrophy, suggesting that the induction of ER resident proteins is coupled to the biogenesis of new ER membrane.
Similar articles
-
Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.Mol Biol Cell. 2003 Jun;14(6):2559-69. doi: 10.1091/mbc.e02-11-0708. Epub 2003 Feb 21. Mol Biol Cell. 2003. PMID: 12808051 Free PMC article.
-
Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases.Plant Physiol. 2001 Nov;127(3):949-62. Plant Physiol. 2001. PMID: 11706177 Free PMC article.
-
The unfolded protein response and Alzheimer's disease.Biochim Biophys Acta. 2001 May 31;1536(2-3):85-96. doi: 10.1016/s0925-4439(01)00049-7. Biochim Biophys Acta. 2001. PMID: 11406343 Review.
-
The cellular response to protein misfolding in the endoplasmic reticulum.Gene Expr. 1999;7(4-6):293-300. Gene Expr. 1999. PMID: 10440230 Free PMC article. Review.
-
The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum.Mol Cell Biol. 1993 Feb;13(2):877-90. doi: 10.1128/mcb.13.2.877-890.1993. Mol Cell Biol. 1993. PMID: 8423809 Free PMC article.
Cited by
-
Unfolding emergency calls stress granules to the ER.Nat Cell Biol. 2024 Jun;26(6):845-846. doi: 10.1038/s41556-024-01434-7. Nat Cell Biol. 2024. PMID: 38822214 No abstract available.
-
Mammalian IRE1α dynamically and functionally coalesces with stress granules.Nat Cell Biol. 2024 Jun;26(6):917-931. doi: 10.1038/s41556-024-01418-7. Epub 2024 May 7. Nat Cell Biol. 2024. PMID: 38714852
-
IRE1 signaling increases PERK expression during chronic ER stress.Cell Death Dis. 2024 Apr 18;15(4):276. doi: 10.1038/s41419-024-06663-0. Cell Death Dis. 2024. PMID: 38637497 Free PMC article.
-
Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure.Curr Hypertens Rep. 2024 Jun;26(6):273-290. doi: 10.1007/s11906-024-01300-9. Epub 2024 Apr 11. Curr Hypertens Rep. 2024. PMID: 38602583 Free PMC article. Review.
-
Cell type-specific regulation of CFTR trafficking-on the verge of progress.Front Cell Dev Biol. 2024 Mar 4;12:1338892. doi: 10.3389/fcell.2024.1338892. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38505263 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials