Neural induction and neurogenesis in amphibian embryos
- PMID: 8542254
Neural induction and neurogenesis in amphibian embryos
Abstract
Neural induction has long been known as the process by which the ectoderm of vertebrate embryos initiates neural development. During this inductive interaction, a region of the embryo called the organizer is a source of inducing signals that directs ectoderm away from an epidermal into a neural fate, thereby forming the neural plate and tube. In this review, we will discuss recent progress in characterizing two molecules in Xenopus embryos, noggin and follistatin, which appear to have many of the properties expected of neural inducers produced by the organizer. In addition, we will discuss progress that has been made in characterizing Xenopus homologs of the neurogenic and proneural genes that control the decision between a neural and epidermal fate in the Drosophila embryos. A model is presented in which these genes act downstream of neural induction in vertebrates to control the generation of neural precursor cells during neurogenesis.
Similar articles
-
Multiple noggins in vertebrate genome: cloning and expression of noggin2 and noggin4 in Xenopus laevis.Gene Expr Patterns. 2006 Jan;6(2):180-6. doi: 10.1016/j.modgep.2005.06.007. Epub 2005 Sep 15. Gene Expr Patterns. 2006. PMID: 16168719
-
[Neural determination in Xenopus laevis embryos: control of early neural gene expression by calcium].J Soc Biol. 2001;195(3):327-37. J Soc Biol. 2001. PMID: 11833471 French.
-
Follistatin and noggin are excluded from the zebrafish organizer.Dev Biol. 1998 Dec 15;204(2):488-507. doi: 10.1006/dbio.1998.9003. Dev Biol. 1998. PMID: 9882485
-
Cell fate determination in embryonic ectoderm.J Neurobiol. 1998 Aug;36(2):128-51. J Neurobiol. 1998. PMID: 9712300 Review.
-
Regional neural induction in Xenopus laevis.Bioessays. 1990 Dec;12(12):591-6. doi: 10.1002/bies.950121206. Bioessays. 1990. PMID: 2080914 Review.
Cited by
-
Cooperative requirement of the Gli proteins in neurogenesis.Development. 2005 Jul;132(14):3267-79. doi: 10.1242/dev.01905. Development. 2005. PMID: 15983404 Free PMC article.
-
Nrarp is a novel intracellular component of the Notch signaling pathway.Genes Dev. 2001 Aug 1;15(15):1885-99. doi: 10.1101/gad.908101. Genes Dev. 2001. PMID: 11485984 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources