Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1995 Oct;141(2):453-64.
doi: 10.1093/genetics/141.2.453.

Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans

Y H Chiu  1 , N R Morris
Affiliations
Comparative Study

Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans

Y H Chiu et al. Genetics. 1995 Oct.

Abstract

Nuclear migration plays an important role in the growth and development of many organisms including the filamentous fungus Aspergillus nidulans. We have cloned three genes from A. nidulans, nudA, nudC, and nudF, in which mutations affect nuclear migration. The nudA gene encodes the heavy chain of cytoplasmic dynein. The nudC gene encodes a 22-kD protein. The nudF gene was identified as an extra copy suppressor of the temperature sensitive (ts-) nudC3 mutation. The nudC3 mutation substantially decreases the intracellular concentration of the nudF protein at restrictive temperature. This is restored toward the normal level by an extra copy of nudF. To identify other genes whose products interact directly or indirectly with the NUDC protein, we have isolated a set of extragenic suppressors showed them to represent nine different genes, designated sncA-sncI (for suppressor of nudC). sncA-sncH were either dominant or semidominant in diploids homozygous for nudC3 and heterozygous for the snc mutations. All of the suppressors reversed the ts- phenotype of nudC3 by restoring the intracellular concentration of the NUDF protein.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Embryol Exp Morphol. 1983 Jun;75:117-39 - PubMed
    1. J Cell Biol. 1994 Oct;127(1):129-38 - PubMed
    1. J Cell Biol. 1987 Jan;104(1):87-95 - PubMed
    1. Dev Biol. 1987 Nov;124(1):9-22 - PubMed
    1. Nature. 1987 Nov 12-18;330(6144):181-3 - PubMed

Publication types

Substances

-