Risk of Parkinson's disease among first-degree relatives: A community-based study
- PMID: 8710070
- DOI: 10.1212/wnl.47.1.155
Risk of Parkinson's disease among first-degree relatives: A community-based study
Abstract
Objective: To determine the relative risk (RR) and cumulative incidence of idiopathic Parkinson's disease (PD) in first-degree relatives of PD patients compared with relatives of controls from the same geographic region.
Design: A family history questionnaire was used to obtain information on all first-degree relatives of cases and controls. A subset of these first-degree relative was also examined. A Cox proportional hazards model with double-censoring techniques for missing information was used to model the RR for PD, adjusting for gender, ethnicity, and relationship to proband.
Results: A total of 1,458 first-degree relatives of 233 PD patients were 2.3 times as likely (95% CI = 1.3 to 4.0) as 7,834 relatives of 1,172 controls to develop PD. The cumulative incidence of PD to age 75 among first-degree relatives of PD patients was 2% compared with 1% among first-degree relatives of controls. The risk in male first-degree relatives was higher than in female relatives (RR = 2.0, 95% CI = 1.1 to 3.4) and the risk in relatives of Caucasians was higher than in African-Americans and Hispanics (RR = 2.4, 95% CI = 1.4 to 4.1). Risk for siblings and parents of probands was similar.
Conclusions: Susceptibility to PD is increased in first-degree relatives of both sporadic and familial cases. The pattern of inheritance and the relationship between genetic and environmental risk factors warrant further study.
Similar articles
-
Risk of Alzheimer's disease in relatives of Parkinson's disease patients with and without dementia.Neurology. 1999 Mar 10;52(4):719-24. doi: 10.1212/wnl.52.4.719. Neurology. 1999. PMID: 10078716
-
Familial aggregation of early- and late-onset Parkinson's disease.Ann Neurol. 2003 Oct;54(4):507-13. doi: 10.1002/ana.10711. Ann Neurol. 2003. PMID: 14520664
-
Lack of familial aggregation of Parkinson disease and Alzheimer disease.Arch Neurol. 2004 Jul;61(7):1033-9. doi: 10.1001/archneur.61.7.1033. Arch Neurol. 2004. PMID: 15262733
-
Familial aggregation of Parkinson's disease in a multiethnic community-based case-control study.Mov Disord. 2010 Nov 15;25(15):2587-94. doi: 10.1002/mds.23361. Mov Disord. 2010. PMID: 20842689 Free PMC article.
-
Risk of action tremor in relatives of tremor-dominant and postural instability gait disorder PD.Neurology. 2003 Oct 14;61(7):931-6. doi: 10.1212/wnl.61.7.931. Neurology. 2003. PMID: 14557562
Cited by
-
Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson's Disease.Biomolecules. 2024 Jan 5;14(1):73. doi: 10.3390/biom14010073. Biomolecules. 2024. PMID: 38254673 Free PMC article. Review.
-
COQ2 variants in Parkinson's disease and multiple system atrophy.J Neural Transm (Vienna). 2018 Jun;125(6):937-944. doi: 10.1007/s00702-018-1885-1. Epub 2018 Apr 11. J Neural Transm (Vienna). 2018. PMID: 29644397
-
OX40 Gene and Serum Protein Expression Profiles in Patients with Parkinson's Disease.Cell J. 2018 Jul;20(2):177-182. doi: 10.22074/cellj.2018.5038. Epub 2018 Mar 18. Cell J. 2018. PMID: 29633594 Free PMC article.
-
The surprising implications of familial association in disease risk.BMC Public Health. 2018 Jan 15;18(1):135. doi: 10.1186/s12889-018-5033-5. BMC Public Health. 2018. PMID: 29334951 Free PMC article.
-
Mimicking Parkinson's Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models.Neuromolecular Med. 2017 Sep;19(2-3):241-255. doi: 10.1007/s12017-017-8454-x. Epub 2017 Jul 18. Neuromolecular Med. 2017. PMID: 28721669 Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical