Activity of once-daily cefpodoxime regimens against Haemophilus influenzae and Streptococcus pneumoniae with an in vitro pharmacodynamic chamber model
- PMID: 8726036
- PMCID: PMC163366
- DOI: 10.1128/AAC.40.6.1545
Activity of once-daily cefpodoxime regimens against Haemophilus influenzae and Streptococcus pneumoniae with an in vitro pharmacodynamic chamber model
Abstract
To characterize the in vitro effectiveness of once-daily dosing with cefpodoxime against Haemophilus influenzae and Streptococcus pneumoniae infections, an in vitro pharmacodynamic chamber model was used to compare the bacterial killing activities of three cefpodoxime regimens: 100 mg twice daily (BID), 200 mg once daily (QD), and 400 mg QD. At the end of 24 h, the regrowth of H. influenzae isolates in the QD regimens was of concern, and the total logarithmic reduction was greatest in the BID regimen (3.1 log). Against S. pneumoniae isolates, the largest reductions in bacterial counts were observed in the 100-mg BID (5.5 log) and 400-mg QD (4.0 log) regimens. These data suggest that 400 mg of cefpodoxime given QD may have a role in the therapy of infections involving S. pneumoniae isolates.
Similar articles
-
The efficacy of cefditoren pivoxil in the treatment of lower respiratory tract infections, with a focus on the per-pathogen bacteriologic response in infections caused by Streptococcus pneumoniae and Haemophilus influenzae: a pooled analysis of seven clinical trials.Clin Ther. 2006 Dec;28(12):2061-9. doi: 10.1016/j.clinthera.2006.12.010. Clin Ther. 2006. PMID: 17296462 Review.
-
Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models.Int J Antimicrob Agents. 2005 Feb;25(2):120-9. doi: 10.1016/j.ijantimicag.2004.09.012. Int J Antimicrob Agents. 2005. PMID: 15664481
-
[Comparative antibacterial activity of cefpodoxime against Haemophilus influenzae, Streptococcus pyogenes, Streptococcus pneumoniae and Moraxella catarrhalis].Arzneimittelforschung. 1994 May;44(5):668-70. Arzneimittelforschung. 1994. PMID: 8024645 German.
-
Clinical experience with cefpodoxime proxetil in acute otitis media.Pediatr Infect Dis J. 1995 Apr;14(4 Suppl):S12-8. doi: 10.1097/00006454-199504001-00003. Pediatr Infect Dis J. 1995. PMID: 7792125 Review.
-
In-vitro activities of trospectomycin, cefpodoxime, and second-generation cephalosporins against Haemophilus influenzae type b.J Antimicrob Chemother. 1990 Apr;25(4):535-9. doi: 10.1093/jac/25.4.535. J Antimicrob Chemother. 1990. PMID: 2141018
Cited by
-
Continuous infusion of beta-lactam antibiotics.Clin Pharmacokinet. 1998 Nov;35(5):391-402. doi: 10.2165/00003088-199835050-00004. Clin Pharmacokinet. 1998. PMID: 9839090 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources