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. 1996 Sep 1;88(5):1583-7.

Targeted disruption of the murine tissue factor gene results in embryonic lethality

J R Toomey  1 , K E Kratzer, N M Lasky, J J Stanton, G J Broze Jr
Affiliations
  • PMID: 8781413
Free article

Targeted disruption of the murine tissue factor gene results in embryonic lethality

J R Toomey et al. Blood. .
Free article

Abstract

Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable from their TF(+/+) and TF(+/-) littermates. By E10.5, TF(-/-) embryos are severely growth retarded, appear nearly bloodless, and are in most cases dead. Initial observations suggest that TF(-/-) embryos are dying of circulatory failure. Approximately 15% of the TF(-/-) embryos survive beyond E10.5, but none complete gestation. Heterozygotes appear normal and free of bleeding complications.

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