Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996;38(1):121-32.
doi: 10.1007/BF01803790.

Anti-invasion drugs

R B Dickson  1 , M D Johnson, M Maemura, J Low
Affiliations
Review

Anti-invasion drugs

R B Dickson et al. Breast Cancer Res Treat. 1996.

Abstract

Most of the pharmaceuticals in clinical practice today for treatment of breast and other cancers are cytotoxic or cytostatic inhibitors of tumor growth. While this type of drug has found its place, along with surgery and radiotherapy, in treatment of disease, the breast cancer death rate has not decreased. This appears to be the result of rising incidence, resistance to therapy, and metastasis of the disease. Since distant metastasis (usually indicated by lymph node involvement) of breast cancer is related only indirectly to tumor size, it would appear that a concerted effort should be made to discover drugs which directly interfere with this complex process. Metastasis appears to depend upon tumor cell motility, dedifferentiation, local invasion, and angiogenesis. Significant progress has been recently made in the creation of new animal models of metastasis and in identifying several new drugs which may be suitable for clinical inhibition of this process. This article reviews current findings on anti-invasion/metastasis drugs with a focus on breast cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Biol Chem. 1992 Feb 5;267(4):2582-7 - PubMed
    1. Pathol Biol (Paris). 1992 Oct;40(8):813-21 - PubMed
    1. Cancer Res. 1993 Mar 15;53(6):1397-402 - PubMed
    1. Pharmacol Ther. 1992;53(2):239-60 - PubMed
    1. Cancer Res. 1989 Apr 15;49(8):1996-2001 - PubMed

Publication types

Substances

LinkOut - more resources

-