Modulation of insulin activities by leptin
- PMID: 8895466
- DOI: 10.1126/science.274.5290.1185
Modulation of insulin activities by leptin
Abstract
Leptin mediates its effects on food intake through the hypothalamic form of its receptor OB-R. Variants of OB-R are found in other tissues, but their function is unknown. Here, an OB-R variant was found in human hepatic cells. Exposure of these cells to leptin, at concentrations comparable with those present in obese individuals, caused attenuation of several insulin-induced activities, including tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1), association of the adapter molecule growth factor receptor-bound protein 2 with IRS-1, and down-regulation of gluconeogenesis. In contrast, leptin increased the activity of IRS-1-associated phosphatidylinositol 3-kinase. These in vitro studies raise the possibility that leptin modulates insulin activities in obese individuals.
Comment in
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Does leptin contribute to diabetes caused by obesity?Science. 1996 Nov 15;274(5290):1151-2. doi: 10.1126/science.274.5290.1151. Science. 1996. PMID: 8966588 No abstract available.
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