doi: 10.1126/science.274.5290.1197.
Mapping of a gene for Parkinson's disease to chromosome 4q21-q23
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- PMID: 8895469
- DOI: 10.1126/science.274.5290.1197
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Mapping of a gene for Parkinson's disease to chromosome 4q21-q23
Science.
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Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.
Comment in
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Genetic complexity and Parkinson's disease. Deane Laboratory Parkinson Disease Research Group.Science. 1997 Jul 18;277(5324):387-8; author reply 389. doi: 10.1126/science.277.5324.387. Science. 1997. PMID: 9518366 No abstract available.
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Genetic complexity and Parkinson's disease.Science. 1997 Jul 18;277(5324):388-9; author reply 389. Science. 1997. PMID: 9518367 No abstract available.
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