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Comparative Study
. 1996 Dec:23 Suppl 1:S83-6.
doi: 10.1093/clinids/23.supplement_1.s83.

Association of enterotoxigenic Bacteroides fragilis with bacteremia

N Kato  1 , H Kato, K Watanabe, K Ueno
Affiliations
Comparative Study

Association of enterotoxigenic Bacteroides fragilis with bacteremia

N Kato et al. Clin Infect Dis. 1996 Dec.

Abstract

Polymerase chain reaction (PCR) assay was compared with cell culture assay performed with use of HT29/C1 (human colonic epithelial) cells for identifying strains of enterotoxin-producing Bacteroides fragilis (ETBF) isolated from extraintestinal specimens. A total of 188 unselected strains obtained over 2 years at a central clinical laboratory in Tokyo were tested. Overall, 35 strains (18.6%) were positive by cell culture and PCR assay, 152 strains were negative by both assays, and 1 strain was negative by cell culture assay but positive by the PCR assay; the same results were obtained in repeated assays. Among 64 strains from blood, 18 (28.1%) were ETBF, a rate that was significantly higher (P < .05) than the 17 ETBF (13.7%) among 124 strains from other sites. These results suggest that PCR assay is a simple and reliable tool for detecting ETBF and that enterotoxin may be a virulence factor in bacteremia caused by B. fragilis.

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