Calretinin-immunoreactive local circuit neurons in area 17 of the cynomolgus monkey, Macaca fascicularis
- PMID: 9057116
Calretinin-immunoreactive local circuit neurons in area 17 of the cynomolgus monkey, Macaca fascicularis
Abstract
The connections of local circuit neurons immunoreactive for calcium-binding protein calretinin (CR-ir) were studied in area 17 of the macaque monkey visual cortex. Most CR-ir neurons were located in layers 2 and 3A. They were polymorphic and included bitufted, multipolar, pyramid-shaped neurons with smooth dendrites and Cajal-Retzius cells. The majority of CR-ir neurons were gamma-aminobutyric acid (GABA)-immunopositive (approximately 90%), and compromised about 14% of the total GABAergic neuron population. The axons of CR-ir cells had local arbors within layers 1-3, but the major trunks descended to deep layers 5 and 6 where they formed dense terminal fields within narrow columns (100-150 microns). This specific innervation of layers 5 and 6 appeared as a distinct feature of area 17 as it was not seen in the adjacent area 18. CR-ir boutons (n = 168) were GABA-ir (95%) and formed symmetric synapses. In layers 1-3, the majority of postsynaptic targets (n = 64) were GABAergic local circuit neurons [postsynaptic target distribution: GABA-positive dendrites (67%) and somata (14%), and GABA-negative dendrites (13%) and spines (6%)]. In deep layers, the most synapses (80%; n = 187) were formed with pyramidal cells where they provided a basket-type innervation [postsynaptic target distribution: GABA-positive dendrites (19%) and somata (1%), and GABA-negative dendrites (50%), spines (20%) and somata (10%)]. Unlike other GABAergic neurons, which innervate mainly pyramidal neurons, the CR-ir subpopulation only has pyramids as a preferred target in the deep layers (layers 5 and 6); however, in the superficial layers of the area 17, selectively form synapses mainly with other GABAergic cells. Thus, the CR-ir neurons appear to have a dual function of disinhibiting superficial layer neurons and inhibiting pyramidal output neurons in the deep layers.
Similar articles
-
Synaptic targets of calretinin-containing axon terminals in macaque monkey prefrontal cortex.Neuroscience. 2005;130(1):185-95. doi: 10.1016/j.neuroscience.2004.08.046. Neuroscience. 2005. PMID: 15561434
-
A novel population of calretinin-positive neurons comprises reelin-positive Cajal-Retzius cells in the hippocampal formation of the adult domestic pig.Hippocampus. 2004;14(3):385-401. doi: 10.1002/hipo.10180. Hippocampus. 2004. PMID: 15132437
-
Local circuit neurons immunoreactive for calretinin, calbindin D-28k or parvalbumin in monkey prefrontal cortex: distribution and morphology.J Comp Neurol. 1994 Mar 1;341(1):95-116. doi: 10.1002/cne.903410109. J Comp Neurol. 1994. PMID: 8006226
-
Synapses, axonal and dendritic patterns of GABA-immunoreactive neurons in human cerebral cortex.Brain. 1990 Jun;113 ( Pt 3):793-812. doi: 10.1093/brain/113.3.793. Brain. 1990. PMID: 2194628 Review.
-
Dopaminergic and GABAergic retinal cell populations in mammals.Microsc Res Tech. 1997 Jan 1;36(1):26-42. doi: 10.1002/(SICI)1097-0029(19970101)36:1<26::AID-JEMT3>3.0.CO;2-X. Microsc Res Tech. 1997. PMID: 9031259 Review.
Cited by
-
The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cereb Cortex. 2024 May 2;34(5):bhae174. doi: 10.1093/cercor/bhae174. Cereb Cortex. 2024. PMID: 38771244 Free PMC article. Review.
-
Pattern of ventral temporal lobe interconnections in rhesus macaques.J Comp Neurol. 2023 Dec;531(18):1963-1986. doi: 10.1002/cne.25550. Epub 2023 Nov 2. J Comp Neurol. 2023. PMID: 37919833
-
The Co-Expression Pattern of Calcium-Binding Proteins with γ-Aminobutyric Acid and Glutamate Transporters in the Amygdala of the Guinea Pig: Evidence for Glutamatergic Subpopulations.Int J Mol Sci. 2023 Oct 9;24(19):15025. doi: 10.3390/ijms241915025. Int J Mol Sci. 2023. PMID: 37834473 Free PMC article.
-
The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens.Front Neurosci. 2023 Jun 26;17:1187758. doi: 10.3389/fnins.2023.1187758. eCollection 2023. Front Neurosci. 2023. PMID: 37434764 Free PMC article.
-
Comparative features of calretinin, calbindin, and parvalbumin expressing interneurons in mouse and monkey primary visual and frontal cortices.J Comp Neurol. 2023 Dec;531(18):1934-1962. doi: 10.1002/cne.25514. Epub 2023 Jun 26. J Comp Neurol. 2023. PMID: 37357562
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources