Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report
- PMID: 9126130
- PMCID: PMC3952979
Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report
Abstract
Malignant transformation has been described in 30% of cases of giant anorectal condyloma acuminatum. The authors report on a 33-year-old man who was heterosexual and HIV negative and who had a giant anal condyloma. Despite aggressive therapy with multiple fulgurations, interferon alpha and isotretinoin, an invasive squamous cell carcinoma of the rectum developed. An abdominoperineal resection was done followed by radiotherapy and chemotherapy, but this treatment regimen was unsuccessful in controlling the progression of his carcinoma. Human papillomavirus (HPV) serotyping in tumoral tissue was positive for HPV types 11 and 16. In patients with giant anorectal condylomas associated with oncogenic HPV, the course of the disease may be aggressive, so they may benefit from early surgical and medical intervention.
On a décrit une évolution maligne dans 30 % des cas de condylome acuminé ano-rectal. Les auteurs décrivent le cas d’un homme de 33 ans, hétérosexuel et non infecté par le VIH, qui avait un condylome anal géant. Malgré une thérapie agressive comportant de multiples fulgurations, l’administration d’interféron alpha et d’isotrétinoïne, un carcinome spinocellulaire invasif du rectum a fait son apparition. On a procédé à une ré-section abdominopérinéale suivie d’une radiothérapie et d’une chimiothérapie, mais ces traitements n’ont pas réussi à enrayer l’évolution du carcinome. Le sérotypage du papillomavirus humain (HPV) de tissus de la tumeur a donné des résultats positifs quant aux types 11 et 16 du HPV. Chez les patients atteints de condylomes ano-rectaux géants associés au HPV oncogène, l’évolution de la maladie peut être brutale et une intervention chirurgicale et médicale rapide peut donc être bénéfique pour les patients en cause.
Similar articles
-
Condyloma Acuminatum of Urinary Bladder: Relation to Squamous Cell Carcinoma.Am J Surg Pathol. 2019 Nov;43(11):1547-1553. doi: 10.1097/PAS.0000000000001339. Am J Surg Pathol. 2019. PMID: 31368913
-
Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature.Dis Colon Rectum. 2001 Dec;44(12):1878-86. doi: 10.1007/BF02234473. Dis Colon Rectum. 2001. PMID: 11742180 Review.
-
Giant condyloma acuminatum (Buschke-Loewenstein tumour) of the anorectum with malignant transformation.Eur J Surg. 1995 Sep;161(9):691-4. Eur J Surg. 1995. PMID: 8541430 No abstract available.
-
Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases.Dis Colon Rectum. 1994 Sep;37(9):950-7. doi: 10.1007/BF02052606. Dis Colon Rectum. 1994. PMID: 8076499 Review.
-
Condylomata acuminata, giant condyloma acuminatum (Buschke-Loewenstein tumour) and verrucous squamous carcinoma of the perianal and anorectal region: a continuous precancerous spectrum?Histopathology. 1985 Nov;9(11):1155-69. doi: 10.1111/j.1365-2559.1985.tb02796.x. Histopathology. 1985. PMID: 4085991
Cited by
-
Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review.J Gastrointest Cancer. 2022 Dec;53(4):1083-1092. doi: 10.1007/s12029-021-00713-y. Epub 2021 Oct 25. J Gastrointest Cancer. 2022. PMID: 34694593 Review.
-
Buschke-Löwenstein Tumour: Successful Treatment with Minimally Invasive Techniques.Case Rep Dermatol Med. 2015;2015:651703. doi: 10.1155/2015/651703. Epub 2015 Aug 31. Case Rep Dermatol Med. 2015. PMID: 26417462 Free PMC article.
-
Proctitis and Sexually Transmissible Diseases of the Colon.Curr Treat Options Gastroenterol. 2003 Jun;6(3):263-270. doi: 10.1007/s11938-003-0008-7. Curr Treat Options Gastroenterol. 2003. PMID: 12744826
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical